Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Venom from Spiders Collected in Southeastern and Northeastern Brazilian Regions Cause Hemotoxic Effects on Human Blood Components.
Toxins (Basel)
December 2024
Molecular Toxinology Lab, Research and Development Department, Ezequiel Dias Foundation-FUNED, Belo Horizonte 30510-010, MG, Brazil.
Spiders of the genus represent a public health problem in Brazil due to the severity of the cutaneous and systemic effects that may result from their bite. In the systemic form of loxoscelism, hemolytic anemia, thrombocytopenia, and disseminated intravascular coagulation can occur. Despite the seriousness of accidents, the venom of some species has not yet been properly characterized considering these hemotoxic effects, such as that of , , and .
View Article and Find Full Text PDFDirect delivery of plasmin using clot-anchoring thrombin-responsive nanoparticles for targeted fibrinolytic therapy.
J Thromb Haemost
April 2023
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, USA. Electronic address:
Background: Fibrin-rich clot formation in thrombo-occlusive pathologies is currently treated by systemic administration of plasminogen activators (e.g. tPA), to convert fibrin-associated plasminogen to plasmin for fibrinolytic action.
View Article and Find Full Text PDFEfficacy and Safety of Direct Hemoperfusion Using Polymyxin B-Immobilized Polystyrene Column for Patients With COVID-19: Protocol for an Exploratory Study.
JMIR Res Protoc
November 2022
Department of Respiratory Medicine, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Background: Polymyxin B-immobilized fiber column (PMX; Toraymyxin column) was approved for the relief of systemic inflammatory response syndrome caused by bacterial infection or endotoxemia. PMX reduces lung damage by removing leukocytes and cytokines in addition to endotoxin removal in the setting of idiopathic pulmonary fibrosis. Acute exacerbation of interstitial pneumonia pathologically presents with diffuse alveolar damage (DAD).
View Article and Find Full Text PDFBleeding and Thrombosis: Insights into Pathophysiology of Venom-Related Hemostasis Disorders.
Int J Mol Sci
September 2021
INSERM, UMRS-1144, Paris University, 75006 Paris, France.
Article Synopsis
- Toxins from venoms can cause serious health issues related to bleeding and clotting disorders, including both local and systemic bleeding problems.
- These venoms contain various types of proteins that can either affect blood coagulation directly or disrupt blood vessel integrity, ultimately leading to conditions like edema and organ failure.
- The mechanisms of these effects include damaging blood vessel structures, altering platelet function, and switching the blood vessel lining to a state that promotes clotting, contributing to both bleeding and thrombosis during envenomation events.
Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression.
Front Immunol
May 2021
Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, TX, United States.
Background: Dynamic D-dimer level is a key biomarker for the severity and mortality of COVID-19 (coronavirus disease 2019). How aberrant fibrinolysis influences the clinical progression of COVID-19 presents a clinicopathological dilemma challenging intensivists.
Methods: We performed meta-analysis and meta regression to analyze the associations of plasma D-dimer with 106 clinical variables to identify a panoramic view of the derangements of fibrinolysis in 14,862 patients of 42 studies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!