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Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation.
Sci Transl Med
November 2024
State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510060, China.
In liver transplantation, donor livers are typically stored in a preservation solution at 4°C for up to 12 hours. However, this short preservation duration can lead to various issues, such as suboptimal donor-recipient matching and limited opportunities for organ sharing. Previous studies have developed a long-term preservation method called supercooling liver preservation (SLP) to address these issues.
View Article and Find Full Text PDFArticle Synopsis
- - Paederus contact dermatitis is a skin condition caused by beetles from the Paederus genus, which release a harmful toxin called paederin, commonly found in hot climates and during rainy seasons.
- - Symptoms include red patches with blisters on the skin, often accompanied by burning and itching, as demonstrated by a case of a 28-year-old male who developed lesions after vacationing in Ecuador.
- - Treatment involves washing the affected area, using topical steroids, and antihistamines; in the reported case, the patient improved significantly after 8 days, although some dark spots remained after the lesions healed.
Hypothalamic hormone deficiency enables physiological anorexia.
bioRxiv
March 2024
Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels lasts for 5-7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24-48-hour periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger during IBAs.
View Article and Find Full Text PDFProlonged cold-preservation of domestic cat ovarian tissue is improved by extracellular solution but impaired by the fragmentation of ovary.
Anim Reprod Sci
April 2024
Department of Reproduction and Clinic of Farm Animals, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 49, Wroclaw 50-366, Poland. Electronic address:
Article Synopsis
- The study investigates the effects of different storage solutions on the preservation of domestic cat ovaries during cold-storage.
- Findings indicate that storing whole ovaries in SP+ solution for 48 hours maintains better follicular morphology compared to DPBS, while UW solution is preferable for ovarian tissue fragments.
- It is recommended that ovarian fragmentation be avoided prior to cold-storage, as it negatively impacts follicular structure preservation.
The Effects of Two Different Cold Application Times on Edema, Ecchymosis, and Pain After Rhinoplasty: A Randomized Clinical Trial.
J Perianesth Nurs
June 2024
Department of Otolaryngology, Head and Neck Surgery, Gulhane Medical School, Ankara, Turkey.
Purpose: This study was performed to determine the effects of different cold application times to the periorbital area after rhinoplasty on edema, ecchymosis, and pain.
Design: A randomized clinical study.
Methods: Patients were divided into two groups, and cold application was applied to one group for 4 hours and to the other for 48 hours.
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