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Thyrotoxic periodic paralysis complicated by carbimazole-associated myositis.
BMJ Case Rep
September 2024
Endocrinology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
A male of East Asian background in his 30s presented to the emergency department with acute onset global muscle weakness, elevated creatine kinase, profound hypokalaemia and hyperthyroidism. A diagnosis of thyrotoxic periodic paralysis was made and the myopathy resolved promptly with potassium replacement. However, 3 months after being commenced on carbimazole for hyperthyroidism, the patient developed myalgias without weakness associated with an elevated creatine kinase.
View Article and Find Full Text PDFMetformin alleviates the dysregulated testicular steroidogenesis and spermatogenesis induced by carbimazole in levothyroxine-primed rats.
Life Sci
October 2022
Department of Clinical Pharmacology, Faculty of Medicine, Portsaid University, Portsaid, Egypt.
Article Synopsis
- Most studies on carbimazole-induced testicular injury have been conducted on healthy animals, limiting their relevance to humans.
- Metformin was tested alongside carbimazole in a rat study to assess its effects on testicular health and thyroid function, showing that higher doses of Metformin helped improve various testicular functions.
- The findings suggest that Metformin can provide protective benefits to testicular health in conditions with thyroid issues, indicating a need for further research on this relationship in diabetic patients.
Psychosis Following Carbimazole-induced Acute Alteration of Hyperthyroid Status.
Indian J Psychol Med
January 2017
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
Abrupt normalization of hyperthyroid state with antithyroid drugs is reported to precipitate psychosis. We report the development of acute psychosis in a 20-year-old woman, following 30 days use of tablet carbimazole 10 mg for hyperthyroidism due to the multinodular goiter. At the time of presentation, she was euthyroid with a resolution of hyperthyroid status both clinically and biochemically.
View Article and Find Full Text PDFCarbimazole-induced acute cholestatic hepatitis.
J Clin Gastroenterol
February 1989
Clinique Thérapeutique, C.H.U. de Rouen, France.
A case of carbimazole-induced cholestatic hepatitis is presented. A woman received carbimazole for hyperthyroidism for 3 months. Five months later, she had prompt recurrence of cholestasis parameters after rechallenge (2 days of treatment).
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