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Abnormal redox balance at membrane contact sites causes axonopathy in -related Charcot-Marie-Tooth disease.
Res Sq
December 2024
Laboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Pathogenic variants of cause Charcot-Marie-Tooth disease (CMT), an inherited neuropathy characterized by axonal degeneration. GDAP1, an atypical glutathione S-transferase, localizes to the outer mitochondrial membrane (OMM), regulating this organelle's dynamics, transport, and membrane contact sites (MCSs). It has been proposed that GDAP1 functions as a cellular redox sensor.
View Article and Find Full Text PDFEngineering of redox-triggered polymeric lipid hybrid nanocarriers for selective drug delivery to cancer cells.
J Mater Chem B
January 2025
School of Biological Sciences, National Institute of Science Education and Research, HBNI, Jatni, Odisha 752050, India.
Tunable redox-sensitive polymeric-lipid hybrid nanocarriers (RS-PLHNCs) were fabricated using homogenization and nanoprecipitation methods. These nanocarriers were composed of novel redox-cholesterol with disulfide linkages and synthesized by conjugating cholesterol with dithiodipropionic acid esterification. Berberine (BBR) was loaded into the fabricated nanocarriers to investigate the selective uptake of BBR by cancer cells as well as its release and enhanced cytotoxicity.
View Article and Find Full Text PDFComputational Study on the Octahedral Surfaces of Magnetite Nanoparticles and Their Solvent Interaction.
Environ Sci Technol
November 2024
Institute of Geological Sciences, University of Bern, 3012 Bern, Switzerland.
Magnetite nanoparticles (MNPs) play an important role in geological and environmental systems because of their redox reactivity and ability to sequester a wide range of metals and metalloids. X-ray absorption spectroscopy conducted at metal and metalloid edges has suggested that the magnetite {111} faces of octahedrally shaped nanoparticles play a dominant role in the redox and sorption processes of these elements. However, studies directly probing the magnetite surfaces, especially in their fully solvated state, are scarce.
View Article and Find Full Text PDFEndosomal pH, Redox Dual-Sensitive Prodrug Micelles Based on Hyaluronic Acid for Intracellular Camptothecin Delivery and Active Tumor Targeting in Cancer Therapy.
Pharmaceutics
October 2024
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
CPT is a pentacyclic monoterpene alkaloid with a wide spectrum of antitumor activity. Its clinical application is restricted due to poor water solubility, instability, and high toxicity. We developed a new kind of multifunctional micelles to improve its solubility, reduce the side effecs, and obtain enhanced antitumor effects.
View Article and Find Full Text PDFArsenic redox disequilibrium in geogenic contaminated groundwater: Bioenergetic insights from organic molecular characterization and gene-informed modeling.
Water Res
December 2024
School of Environmental Studies, China University of Geosciences, 430074 Wuhan, China; MOE Key Laboratory of Groundwater Quality and Health, China University of Geosciences, 430074 Wuhan, China; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, 430074 Wuhan, China. Electronic address:
Biotransformation of arsenic (As) influences its speciation and mobility, obscuring mechanistic comprehension on spatiotemporal variation of As concentration in geogenic contaminated groundwater. In particular, unresolved processes underlying As redox disequilibrium in comparison to major redox couples discourage practical efforts to rehabilitate the As-contaminated groundwater. Here, quantitative metagenomic sequencing and ultrahigh-resolution mass spectrometry (FT-ICR-MS) were jointly applied to reveal the links between vertical distribution of As metabolic gene assemblages and that of free energy density of dissolved organic matter (DOM) in As-contaminated groundwater of Datong Basin.
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