[Preparation of rat model of systemic inflammatory response syndrome induced by zymosan].

Objective: To establish a model of systemic inflammatory response syndrome (SIRS) in rats.

Methods: SD rats were intraperitoneally injected with different concentrations of zymosan suspension. The general status, temperature, white cell count, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-10 (IL-10) and the pathological changes of main organs were examined.

Results: The conditions of rats receiving zymosan doses of 750 mg/kg and 1000 mg/kg were consistent with the criteria of SIRS model; however, the mortality of 1000 mg/kg group was higher than that of 750 mg/kg group.

Conclusion: The rat model of systemic inflammatory response syndrome has been successfully induced.