The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the genetic and biochemical features of LCAT deficiency, highlighting the absence of enhanced preclinical atherosclerosis in carriers, despite the remarkably low HDL cholesterol.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.atherosclerosis.2011.11.034 | DOI Listing |
Publication Analysis
Top Keywords
lecithincholesterol acyltransferase
8
lcat deficiency
8
low hdl
8
hdl cholesterol
8
genetic lecithincholesterol
4
acyltransferase deficiency
4
deficiency cardiovascular
4
cardiovascular disease
4
disease lecithincholesterol
4
acyltransferase lcat
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!