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Background: Progranulin (PGRN), a glycoprotein secreted by microglia and neurons, regulates lysosomal function, neuroinflammation, and has neurotrophic effects. Variants in the granulin gene (GRN) that cause a reduction of PGRN in plasma and cerebrospinal fluid (CSF) are associated with an increased risk of Alzheimer's disease (AD). The sortilin receptor (SORT1) on neurons and microglia regulates PGRN degradation.
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College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Background: The emergence of dementia as a global health challenge necessitates an exploration of its unique epidemiological patterns and risk factors in Sub-Saharan Africa (SSA). Amid a growing elderly population, SSA presents an intriguing paradox of lower-than-expected dementia prevalence, prompting a comprehensive review of epidemiological nuances, lifestyle risk factors, cultural influences, and protective factors. This study critically assessed the current state of dementia research in SSA, aiming to inform tailored interventions and policies.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
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UOC Geriatria - Disturbi Cognitivi e Demenza; AUSL Modena, Modena, Italy.
Background: Social restrictions and closures of services due to COVID-19 pandemic had a negative impact on the social inclusion and well-being of older people. In fact, older adults present risk factors both in terms of health - such as frailty or multimorbidity - and in terms of quality of life - for example institutionalization - and poor social support. The main objective is to evaluate whether social support had the role of an effect modifier on the incidence of cognitive frailty.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
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Yonsei University, Wonju, Gangwon-do, Korea, Republic of (South).
Background: Self-rated health status goes beyond a mere indicator of one's well-being, encompassing biological, social, and functional aspects. It has emerged as a significant variable in predicting mortality. Against this backdrop, understanding the impact of subjective health status on anxiety symptoms is crucial for individuals with dementia.
View Article and Find Full Text PDFDementia Care Practice.
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Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Persons living with dementia (PLWD) are twice as likely to use the emergency department (ED) and 1.5 times more likely to have an avoidable ED visit than elders without dementia. PLWD have greater comorbidity, incur higher charges, are admitted to hospitals at higher rates, return to EDs at higher rates, and have higher mortality after an ED visit than patients without dementia.
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