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Evaluation of unitary conductance of gap junction channels based on stationary fluctuation analysis.
Methods
January 2025
Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas 50103, Lithuania; Department of Mathematical Modelling, Kaunas University of Technology, Kaunas 51368, Lithuania.
Gap junction (GJ) channels, formed of connexin (Cx) protein, enable direct intercellular communication in most vertebrate tissues. One of the key biophysical characteristics of these channels is their unitary conductance, which can be affected by mutations in Cx genes and various biochemical factors, such as posttranslational modifications. Due to the unique intercellular configuration of GJ channels, recording single-channel currents is challenging, and precise data on unitary conductances of some Cx isoforms remain limited.
View Article and Find Full Text PDFPhytochemical Profile, Acute and Subacute Toxicity of Spray-Dried Hydroethanolic Extract from Punica granatum Leaves.
Chem Biodivers
January 2025
Universidade Federal de Pernambuco, Pharmaceutical Sciences, Rua Prof Arthur de Sá, SN, 50740521, Recife, BRAZIL.
This study aimed to provide a comprehensive understanding of the acute and subacute safety and phytochemical profile of pomegranate leaves, aligning with the growing interest in sustainable, plant-based therapeutics. The phytochemical composition, the acute and subacute toxicity of a spray-dried hydroethanolic extract from pomegranate leaves (SDE) were investigated using experimental animal models. Utilizing UV-visible spectrophotometry and liquid chromatography-mass spectrometry (LC-MS), a diverse array of tannins and flavonoids, totaling 38 compounds, was identified.
View Article and Find Full Text PDFInfection survey, molecular, pathogenicity, and morphological characteristics of Sarcocystis species naturally infected water buffaloes (Bubalus bubalis) in Egypt.
BMC Vet Res
December 2024
Zoology and Entomology Department, Faculty of Science, Al-Azhar University (Girl's Branch), Cairo, Egypt.
Background: Sarcocystosis is a parasitic disease found worldwide, resulting from various Sarcocystis species. The current research was carried out in three significant economic areas in Egypt: Greater Cairo, the Nile Delta, and Upper Egypt. It aimed to investigate the occurrence of Sarcocystis spp.
View Article and Find Full Text PDFBreaking Performance Barriers in KBeBOF (KBBF) Analogs by Functional Group Self-Polymerization.
Angew Chem Int Ed Engl
December 2024
College of Chemistry, Sichuan University, Chengdu, 610065, P. R. China.
Article Synopsis
- Development of KBeBOF analog crystals enhances conversion efficiency for all-solid-state lasers.
- Two new optical crystals were synthesized: noncentrosymmetric CsAsOBr and centrosymmetric CsAsOBr, optimizing linear and nonlinear optical properties through self-polymerization of functional groups.
- CsAsOBr shows a 20.5 times stronger second-harmonic generation response than KDP and exceptional birefringence, marking a significant improvement for future UV NLO materials and photonic technologies.
Power Strokes in Molecular Motors: Predictive, Irrelevant, or Somewhere in Between?
J Am Chem Soc
January 2025
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
For several decades, molecular motor directionality has been rationalized in terms of the free energy of molecular conformations visited before and after the motor takes a step, a so-called power stroke mechanism with analogues in macroscopic engines. Despite theoretical and experimental demonstrations of its flaws, the power stroke language is quite ingrained, and some communities still value power stroke intuition. By building a catalysis-driven motor into simulated numerical experiments, we here systematically report on how directionality responds when the motor is modified accordingly to power stroke intuition.
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