Background: The aim of this study was to perform the first femtosecond laser cuts with a new prototype femtosecond laser, in vivo and to evaluate its safety, stability and efficacy.
Methods: A LASIK cut was performed with a prototype 200 kHz femtosecond laser in both eyes of nine patients and one eye of two patients (20 individual eyes in total). A complete ophthalmic examination was performed preoperatively and postoperatively at 1, 3, 6 and 12 months after the procedure.
Results: In the pilot series of 20 eyes, flap creation was possible in each case. The mean preoperative manifest refractive spherical equivalent was À-4.22 D (SD ± 61.22 D). The postoperative spherical equivalent refraction was À-0.1 D (SD ± 60.26 D) at 1 month, À-0.22 D (SD ± 60.24 D) at 3 months and À-0.15 D (SD ± 60.16 D) 12 months after surgery.
Conclusions: Femto-LASIK with this new laser system showed high levels of safety, stability and efficacy without any enhancement.
Clinical Trials Registration: http://www.dimdi.de. DE/CA126/AP4/3332/27/09. Bfam registration 09/03/2009, DE/CA126.
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http://dx.doi.org/10.1136/bjophthalmol-2011-300073 | DOI Listing |
BMC Ophthalmol
December 2024
School of Medicine, Xiamen Eye Center and Eye Institute of Xiamen University, Xiamen, 361000, China.
Purepose: The intraoperative femtosecond laser time, Cumulative Dissipated Energy (CDE), Effective Phacoemulsification time (EPT), and intraoperative fluid perfusion volume were compared under different model fragmentation modes using Catalys femtosecond laser system.
Methods: This was a single-center, prospective, randomized controlled study. A total of 120 eyes who underwent femtosecond laser-assisted cataract phacoemulsification combined with intraocular lens implantation in Xiamen Eye Center affiliated to Xiamen University from September 2022 to March 2023 were randomly divided into 4 groups to undergo pre-nucleus splitting in different ways: Group 1: six-split, Group 2: eight-split, Group 3: six-split + gridded softening, and Group 4: eight-split + gridded softening.
Biosensors (Basel)
November 2024
Institute of Laser Engineering, Osaka University, Suita 565-0871, Osaka, Japan.
Biosensors operating in the terahertz (THz) region are gaining substantial interest in biomedical analysis due to their significant potential for high-sensitivity trace-amount solution detection. However, progress in compact, high-sensitivity chips and methods for simple, rapid and trace-level measurements is limited by the spatial resolution of THz waves and their strong absorption in polar solvents. In this work, a compact nonlinear optical crystal (NLOC)-based reflective THz biosensor with a few arrays of asymmetrical meta-atoms was developed.
View Article and Find Full Text PDFAdv Mater
December 2024
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHK-Shenzhen), Shenzhen, Guangdong, 518172, P. R. China.
The existence of residual small-size tumors after surgery is a major factor contributing to the high recurrence rate of glioblastoma (GBM). Conventional adjuvant therapeutics involving both chemotherapy and radiotherapy usually exhibit unsatisfactory efficacy and severe side effects. Recently, two-photon photodynamic therapy (TP-PDT), especially excited by the second near-infrared (NIR-II) light, offers an unprecedented opportunity to address this challenge, attributed to its combinational merits of PDT and TP excitation.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Institute of Materials Science and Engineering, Chemnitz University of Technology, Erfenschlager Straße 73, Chemnitz 09125, Germany.
The generation of laser-induced periodic surface structures (LIPSS) using femtosecond lasers facilitates the engineering of material surfaces with tailored functional properties. Numerous aspects of their complex formation process are still under debate, despite intensive theoretical and experimental research in recent decades. This particularly concerns the challenge of verifying approaches based on electromagnetic effects or hydrodynamic processes by experiment.
View Article and Find Full Text PDFAnal Chem
December 2024
State Key Laboratory of Continental Dynamics, Department of Geology, Northwest University, Xi'an 710069, China.
Matrix effects can significantly bias Hf isotopic ratios in situ Hf isotope analyses using laser ablation (LA-) multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS), necessitating the use of matrix-matched reference materials for accurate microanalysis. This work introduces a novel fast hot-pressing (FHP) sintering method to produce such reference materials efficiently for in situ analysis. By optimizing sintering temperatures, FHP technology enables the rapid preparation of in situ analysis reference materials with dense structures and homogeneous Hf isotopic compositions.
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