Purpose: Death at the beginning of life is tragic but not uncommon in neonatal intensive care units. In Portugal, few studies have examined the circumstances surrounding the final moments of neonates. We evaluated the care given to neonates and their families in terminal situations and the changes that had occurred one decade later.
Design And Methods: We analyzed 256 charts in a retrospective chart review of neonatal deaths between two periods (1992-1995 and 2002-2005) in a level III neonatal intensive care unit.
Results: Our results show differences in the care of dying infants between the two periods. The analysis of the 2002-2005 cohort four years revealed more withholding and withdrawing of therapeutic activities and more effective pain and distress relief; however, on the final day of life, 95.7% of the infants received invasive ventilatory support, 76.3% received antibiotics, 58.1% received inotropics, and 25.8% received no opioid or sedative administration. The 2002-2005 cohort had more spiritual advisor solicitation, a higher number of relatives with permission to freely visit and more clinical meetings with neonatologists. Interventions by parents, healthcare providers and ethics committees during decision-making were not documented in any of the charts. Only eight written orders regarding therapeutic limitations and the adoption of palliative care were documented; seven (87.5%) were from the 2002-2005 cohort. Parental presence during death was more frequent in the latter four years (2002-2005 cohort), but only 21.5% of the parents wanted to be present at that moment.
Conclusion: Despite an increase in the withholding and withdrawing of therapeutic activities and improvements in pain management and family support, many neonates still receive curative and aggressive practices at the end of life.
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http://dx.doi.org/10.1590/s1807-59322011000900011 | DOI Listing |
BMC Public Health
November 2024
Children's Environmental Health Initiative, University of Illinois Chicago, Chicago, IL, USA.
Background: Residential instability and neighborhood conditions may shape children's health and development, but it is unclear whether all residential moves are equally destabilizing, and the extent to which moving to neighborhoods with different conditions can improve children's outcomes. Most studies estimating causal effects of these factors on children's health or development use smaller, geographically constrained, urban cohorts.
Objective: In a racially/ethnically and socioeconomically diverse statewide cohort including urban and rural communities, we investigate effects of residential instability, neighborhood deprivation, and their intersection on childhood educational outcomes.
Neurol Clin Pract
February 2025
Department of Biomedical Sciences (MK, SJP, JS, HJK, Jooyoung Chang, SP, JK, HL, SMP), Seoul National University Hospital, Seoul National University College of Medicine; College of Nursing (MK), Korea University, Seoul; Medical Research Center (YJP), Genomic Medicine Institute, Seoul National University; Department of Public Health (Jiwon Choi), Graduate School of Public Health, Seoul National University; Department of Family Medicine (SNO), National Health Insurance Service Ilsan Hospital, Goyang; Department of Medicine (SNO), Yonsei University Graduate School, Seoul; Department of Medical Informatics (SJ), Korea University College of Medicine, Seoul; Department of Family Medicine (KHK, SMP), Seoul National University Hospital, Seoul National University College of Medicine; Comprehensive Care Clinic (KHK), Public Healthcare Center, Seoul National University Hospital; and Department of Internal Medicine (JSS), Hanyang University Hospital, Seoul, South Korea.
Background And Objectives: Recent studies have suggested that antibiotics could be a contributing factor to Parkinson disease (PD), but validation in other population cohorts, such as Asians, is needed. This study examined the association between exposure to antibiotics and PD risk in the Korean population.
Methods: Using the National Health Insurance Service (NHIS) database, this population-level cohort research study from Korea included 298,379 people aged 40 years and older who underwent a national health examination in 2004-2005.
Int Dent J
November 2024
Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Guizhou Medical University, Guiyang, China. Electronic address:
Nutr Metab Cardiovasc Dis
January 2025
Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
J Nutr
October 2024
Department of Medicine/Preventive Medicine and Epidemiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States. Electronic address:
Background: Eggs are rich in bioactive compounds, including choline and carotenoids that may benefit cardiometabolic outcomes. However, little is known about their relationship with nonalcoholic fatty liver disease (NAFLD).
Objectives: We investigated the association between intakes of eggs and selected egg-rich nutrients (choline, lutein, and zeaxanthin) and NAFLD risk and changes in liver fat over ∼6 y of follow-up in the Framingham Offspring and Third Generation cohorts.
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