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Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial).
BMJ Open
January 2025
Mental health Centre Copenhagen, Mental Health Services in the Capital Region of Denmark, Frederiksberg, Denmark.
Introduction: Alcohol use disorder (AUD) is a massive burden for the individual, relatives and society. Despite this, the treatment gap is wide compared with other mental health disorders. Treatment options are sparse, with only three Food and Drug Administration (FDA)-approved pharmacotherapies.
View Article and Find Full Text PDFIntrauterine metformin exposure and adiposity outcomes in children: a systematic review and meta-analysis.
BMJ Open
January 2025
Department of Medicine, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
Objective: The study aims to assess the effect of intrauterine metformin exposure on offspring adiposity measures in childhood.
Design: Systematic review and meta-analysis.
Data Sources: Medline, Embase and Cochrane Central were searched from inception to 4 October 2024.
A Systematic Review of Aspilia africana (Pers.) C.D. Adams Traditional Medicinal Uses, Phytoconstituents, Bioactivities, and Toxicities.
Pharmacol Res
January 2025
Korean Convergence Medical Science Major, Korea National University of Science and Technology (UST), Daejeon, 34113, South Korea; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine (KIOM), 111 Geonjae-Ro, Naju-Si, South Korea. Electronic address:
Aspilia africana (Pers.) C. D.
View Article and Find Full Text PDFhaploinsufficiency in a mother-daughter pair with young-onset diabetes with and without neonatal hypoglycemia.
Clin Pediatr Endocrinol
January 2025
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
The ATP-binding cassette transporter subfamily C member 8 (ABCC8) regulates insulin secretion from β-cells. Loss- and gain-of-function variants of have been implicated in neonatal hyperinsulinemic hypoglycemia and young-onset diabetes, respectively. Although some patients with variants have been reported to exhibit both neonatal hypoglycemia and young-onset diabetes, the molecular and clinical characteristics of this atypical phenotype remain unknown.
View Article and Find Full Text PDFChanges of CA19-9 levels and related influencing factors in patients with type 2 diabetes mellitus after antidiabetic therapy.
Sci Rep
January 2025
Affiliated Xiaoshan Hospital, Hangzhou Normal University/Zhejiang Xiaoshan Hospital, 728 Yucai North Road, Hangzhou, 311200, China.
Abnormalities of carbohydrate antigen 19 - 9 (CA19-9) are common in patients with type 2 diabetes mellitus (T2DM), and in some patients, CA19-9 returns to normal level after glycemic control. The aim of this study was to investigate the factors associated with CA19-9 levels in patients with T2DM and the associated influences on the degree of reduction of CA19-9 levels after antidiabetic therapy (AT). This study was an observational cross-sectional study.
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