Zotepine is an antipsychotic used in Japan and Europe for years and recently being introduced in Indian markets. It is claimed to be particularly effective for negative symptoms, and somnolence and weight gain are the most common side effects. Our aim is to share our clinical experience of use of zotepine with respect to its tolerability. We reviewed the first 10 patients who were prescribed zotepine at our center.
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Tolerability of zotepine in Indian patients: Preliminary experience.
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Deva Mental Health Care, Deva Institute of Healthcare and Research Pvt. Ltd., Varanasi, Uttar Pradesh, India.
Zotepine is an antipsychotic used in Japan and Europe for years and recently being introduced in Indian markets. It is claimed to be particularly effective for negative symptoms, and somnolence and weight gain are the most common side effects. Our aim is to share our clinical experience of use of zotepine with respect to its tolerability.
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December 2000
Klinik für Psychiatrie und Psychotherapie I, Johann Wolfgang Goethe-Universität, Frankfurt/M.
After the introduction of the so-called "atypical neuroleptics" in the clinical experience a marked weight gain was frequently observed in patients treated with some of these agents. In this review the frequency, amount and conditions of weight gain during the medication with 'atypical' neuroleptics were evaluated. A comparison is limited by the different designs and recruitment procedures of the reviewed studies.
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August 1999
Department of Psychiatry, Lübeck University School of Medicine, Germany.
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View Article and Find Full Text PDF[Body weight increase: a side effect of zotepin (Nipolept)?].
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March 1996
Klinik für Psychiatrie, Medizinische Universität zu Lübeck.
During our clinical experience with the new neuroleptic drug zotepine we saw some cases of marked weight gain. This retrospective chart review of 110 cases consecutively admitted with the ICD-10 diagnosis of schizophrenia, schizoaffective or delusional disorder (F20-F25) in 1991 and 1992 was aimed at showing whether the weight gain is due to accidental observations or must be considered a side effect of this new drug. The data analysis of all cases treated longer than 2 weeks with a neuroleptic revealed that cases treated with zotepine showed a significant weight gain (3.
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March 1995
Psychiatry Department I, University of Ulm, Weissenau Psychiatric Hospital, Ravensburg-Weissenau, Germany.
The combination of antidepressive and antipsychotic (neuroleptic) medication is often used in the psychopharmacological treatment of delusional depression. In most studies of the treatment of delusional depression, tricyclic antidepressants have been used, and very little has been written about experience with SSRIs such as fluvoxamine, fluoxetine, or paroxetine. This paper therefore presents the preliminary findings of an open clinical study in which 14 delusional depressed inpatients, consecutively admitted to our Depression Unit, were given paroxetine combined with either zotepine or haloperidol.
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