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Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence.
Pain Ther
January 2025
Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185, Rome, Italy.
Introduction: Elbow ailments are common, but conventional treatment modalities have shortcomings, offering only interim pain relief rather than targeting the underlying pathophysiology. The last two decades have seen a marked increase in the use of autologous peripheral blood-derived orthobiologics (APBOs), such as platelet-rich plasma (PRP), to manage elbow disorders. Platelet-rich plasma (PRP) is the most widely used APBO, but its efficacy remains debatable.
View Article and Find Full Text PDFCausal associations between childhood obesity and delayed puberty or height: a bidirectional two-sample Mendelian randomization study.
J Pediatr Endocrinol Metab
January 2025
Department of Pediatric Endocrinology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Objectives: Childhood obesity is thought to influence pubertal development, according to observational studies. However, the exact causal relationship remains unclear due to the complexity of factors affecting pubertal development.
Methods: To explore the association between exposure (childhood obesity) and outcome (delayed puberty, height), we utilized various methods, including inverse-variance weighted (IVW), weighted median, weighted mode, and MR Egger regression.
National Trends in Non-Accidental Pediatric Craniofacial Fractures Requiring Inpatient Admission.
J Craniofac Surg
January 2025
Department of Pediatric Plastic & Reconstructive Surgery, Children's Hospital Colorado.
Introduction: Pediatric craniofacial trauma, particularly from non-accidental trauma (NAT), is a significant cause of injury with enduring physical and psychological impacts. This study analyzes demographic patterns, injury characteristics, and trends in NAT-related craniofacial injuries to inform early identification, intervention, and prevention efforts.
Methods: Analysis of the Healthcare Cost and Utilization Project Kids' Inpatient Database was performed for the years 2009 to 2019.
Dioxins and their impact: a review of toxicity, persistence, and novel remediation strategies.
Anal Methods
January 2025
Air Resource, Environmental Resource Planning and Management, CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440020, India.
Dioxins rank among the most hazardous persistent organic pollutants, presenting a serious threat due to their long environmental lifespan and capacity for bioaccumulation. This comprehensive review delves into the historical, chemical, and toxicological aspects of dioxins, spotlighting significant incidents such as the Seveso disaster and the repercussions of Agent Orange. The review offers a thorough analysis of the sources of dioxin formation, encompassing natural occurrences like volcanic eruptions and wildfires, alongside man-made activities such as industrial combustion and waste incineration.
View Article and Find Full Text PDFMftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration.
Elife
January 2025
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Junior Research Group Synthetic Microbiology, Jena, Germany.
Mycofactocin is a redox cofactor essential for the alcohol metabolism of mycobacteria. While the biosynthesis of mycofactocin is well established, the gene , which encodes an oxidoreductase of the glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes are almost exclusively found in genomes containing mycofactocin biosynthetic genes and are present in 75% of organisms harboring these genes.
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