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[Circadian rhythms in the toxic effects of the histamine antagonist cetirizine in mice].
Pathol Biol (Paris)
May 2005
Laboratoire de pharmacologie, faculté de médecine, Monastir, Tunisie.
Unlabelled: Cetirizine is a second generation histamine H(1) receptor antagonist used to provide symptomatic relief of allergic signs caused by histamine release. The aim of the study was to learn whether the survival and the motor incoordination (ataxia) side effect of cetirizine administration is dosing time-dependent.
Materials And Methods: A total of 240 male Swiss mice, 10 weeks of age were synchronized for 3 weeks by 12 h light (rest span)/12 h dark (activity span).
Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice.
Chronobiol Int
November 2003
Laboratoire d'Immuno-Oncologie Moléculaire, Faculté de Médecine, Monastir, Tunisia.
The aim of the study was to learn whether the lethal and the motor incoordination (ataxia) side effect of ondansetron (Zophren) administration is dosing-time dependent. Ondansetron is a serotonin 5-HT3 receptor antagonist used primarily to control nausea and vomiting arising from cytotoxic chemo- and radiotherapy. A total of 210 male Swiss mice 10 to 12 weeks of age were synchronized for 3 weeks by 12 h light (rest span)/12 h dark (activity span).
View Article and Find Full Text PDFChronotoxicologic studies on dichlorphos in mice and humans.
Prog Clin Biol Res
November 1990
Department of Public Health, Suzhou Medical College.
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