Recent work has raised the possibility that chromatin modifications pre-set embryonic patterns of gene expression. In this issue of Developmental Cell, Lindeman et al. (2011) support this observation and describe how the pattern of several chromatin marks evolves over the transition from maternal to zygotic control of development.
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http://dx.doi.org/10.1016/j.devcel.2011.11.014 | DOI Listing |
Sci Adv
November 2024
Department of Entomology, University of Maryland, 4291 Fieldhouse Dr., College Park, MD 20742, USA.
Morphological features of organismal body plans are often highly conserved within large taxa. For example, segmentation is a shared and defining feature of all insects. Screens in identified genes responsible for the development of body segments, including the "pair-rule" genes (PRGs), which subdivide embryos into double-segment units in a previously unexpected pre-patterning step.
View Article and Find Full Text PDFCurr Biol
November 2024
Laboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, 1211 Geneva, Switzerland; SIB Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland. Electronic address:
The glabrous skin of the rhinarium (naked nose) of many mammalian species exhibits a polygonal pattern of grooves that retain physiological fluid, thereby keeping their nose wet and, among other effects, facilitating the collection of chemosensory molecules. Here, we perform volumetric imaging of whole-mount rhinaria from sequences of embryonic and juvenile cows, dogs, and ferrets. We demonstrate that rhinarial polygonal domains are not placode-derived skin appendages but arise through a self-organized mechanical process consisting of the constrained growth and buckling of the epidermal basal layer, followed by the formation of sharp epidermal creases exactly facing an underlying network of stiff blood vessels.
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June 2024
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Axis formation in fish and amphibians typically begins with a prepattern of maternal gene products. Annual killifish embryogenesis, however, challenges prepatterning models as blastomeres disperse and then aggregate to form the germ layers and body axes. We show that , a prepatterning factor thought to break symmetry by stabilizing β-catenin, is truncated and inactive in .
View Article and Find Full Text PDFNat Cell Biol
June 2024
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
Dynamic changes in mechanical microenvironments, such as cell crowding, regulate lineage fates as well as cell proliferation. Although regulatory mechanisms for contact inhibition of proliferation have been extensively studied, it remains unclear how cell crowding induces lineage specification. Here we found that a well-known oncogene, ETS variant transcription factor 4 (ETV4), serves as a molecular transducer that links mechanical microenvironments and gene expression.
View Article and Find Full Text PDFFront Cell Dev Biol
March 2024
Universidad de Buenos Aires, Facultad de Medicina, Departamento de Biología Celular e Histología / 1° U.A. Departamento de Histología, Embriología, Biología Celular y Genética, Laboratorio de Embriología Molecular "Prof. Dr. Andrés E. Carrasco", Buenos Aires, Argentina.
The establishment of the embryonic dorsoventral axis in occurs when the radial symmetry around the egg's animal-vegetal axis is broken to give rise to the typical symmetry of Bilaterians. We have previously shown that the Notch1 protein is ventrally enriched during early embryogenesis in and zebrafish and exerts ventralizing activity through β-Catenin destabilization and the positive regulation of ventral center genes in . These findings led us to further investigate when these asymmetries arise.
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