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| http://dx.doi.org/10.3201/eid1712.110739 | DOI Listing |
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Hypertonic Saline Induces Host Protective Immune Responses against Infection in Mice.
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Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Hypertonic saline (HTS) resuscitation can enhance immune responses against various pathogens, however, the effect of HTS on brucellosis is yet to be defined. In this study, we found that HTS inhibited infection in mice by augmenting Th1 immunity. HTS treatment enhanced the serum cytokines production and the expression of nitric oxide synthase (NOS2) and nuclear factor kappa B (NF-ĸB) p50 and p65, crucial anti- effectors in splenocytes.
View Article and Find Full Text PDFIntracellular growth of Brucella is mediated by Dps-dependent activation of ferritinophagy.
EMBO Rep
September 2023
College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea.
Bacteria of the genus Brucella cause brucellosis, one of the world's most common zoonotic diseases. A major contributor to Brucella's virulence is the ability to circumvent host immune defense mechanisms. Here, we find that the DNA-binding protein Dps from Brucella is secreted within the macrophage cytosol, modulating host iron homeostasis and mediating intracellular growth of Brucella.
View Article and Find Full Text PDFBrucellosis knowledge and preventive practices among herders in Western Mongolia.
Zoonoses Public Health
February 2019
School of Public Health, Taipei Medical University, Taipei, Taiwan.
Lack of knowledge regarding brucellosis may lead to highly risky practices. Among herders in Mongolia, little research was conducted assessing the extent of knowledge related to brucellosis, the type of preventive behaviours that were practiced, and the relationship between knowledge and behaviour regarding brucellosis. A cross-sectional study was conducted in two provinces of Mongolia where herders were randomly selected to participate in the study.
View Article and Find Full Text PDFThe medical diagnostic approaches with phylogenetic analysis for rare Brucella spp. diagnosis in Taiwan.
Biomedicine (Taipei)
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Department of Laboratory Medicine, China Medical University Hospital, 404, Taichung, Taiwan.
Brucellosis is a bacterial zoonotic disease which can be easy to misdiagnose in clinical microbiology laboratories. In the present study, we have tried to improve the current clinical method for detecting Brucella spp. and its antibiotic characteristics.
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Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan; Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan. Electronic address:
The commonest ways of diagnosing brucellosis in animals include the Rose-Bengal plate agglutination test, the buffered plate agglutination test (BPA), the slide agglutination test, the complement fixation test, and the indirect enzyme linked immunosorbent assay (I-ELISA). However, these methods cannot discriminate the Brucella vaccine strain (Brucella suis strain 2; B. suis S2) from naturally acquired virulent strains.
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