The paper gives the results of calculation-theoretical studies estimating the effect of the etiotropic agent Relenza (in preventing influenza in its susceptible patients an in treating patients ill with influenza) on the epidemic of pandemic A(H1N1)/2009 influenza in a large city of Russia. The values of its effect (the number of prevented cases of influenza and that of prevented deaths from its complications) have been calculated on a computer, by applying a modified PSEEI2RF influenza epidemic model (a Russian Baroyan-Rvachev model) with the A(H1N1)/2009 influenza pathogen that dominated in the 2009-2010 season in many countries of the world. Predictive estimates of the action of Relenza on the epidemic of A(H1N1)/2009 influenza have been obtained for 5 scenarios while implementing measures to treat patients with the illness and to prevent its susceptible patients in a large city with a population of one million. In conclusion, there are results of predicting the number of prevented A(H1N1)/2009 influenza cases and damage estimates for 6 cities of Russia due to the massive use of the antiviral drug Relenza.
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Front Immunol
January 2018
Department of Public Health, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Purpose: In the elderly population, the influenza infection and its clinical complications are important causes of hospitalization and death, particularly, in longer-lived age. The objective of this study is to analyze the impact of influenza virus circulation on mortality in the elderly and adults, in years with different predominant virus strains.
Methods: We performed a time trend study to evaluated excess of mortality for pneumonia and influenza, respiratory disease, and all-causes in southern region of Brazil, from 2002 to 2015.
Bioinformation
August 2013
Laboratorio de Bioinformática y Biología Molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Av. Honorio Delgado, 430. SMP. Lima, Peru ; Drug R&D Unit, Center for Applied Pharmacobiology Research, University of Navarra, C/ Irunlarrea s/n, 31008, Pamplona, Spain.
The pandemic influenza AH1N1 (2009) caused an outbreak of human infection that spread to the world. Neuraminidase (NA) is an antigenic surface glycoprotein, which is essential to the influenza infection process, and is the target of anti-flu drugs oseltamivir and zanamivir. Currently, NA inhibitors are the pillar pharmacological strategy against seasonal and global influenza.
View Article and Find Full Text PDFRev Peru Med Exp Salud Publica
December 2011
Servicio de Infectología, Instituto Nacional de Salud del Niño, Lima, Perú.
Objective: To determine the clinical and demographic characteristics of pneumonia with influenza virus AH1N1/2009 pandemic at the National Institute of Child.
Methods: Retrospective case series in children hospitalized for influenza pneumonia pandemic AH1N1/2009 in a pediatric hospital. Reviewed the medical records between the months of June to September 2009.
Salud Publica Mex
February 2012
Departamento de Enfermedades Infecciosas, Instituto Nacional de Cancerología (INCan), Ciudad de México.
Respiratory virus epidemics had highlighted the importance of the Intensive Care Unit (ICU) to save life of severe cases. ICU functioning and outcomes depends on infrastructure and trained healthcare personnel. In Chiapas, a Southern state in Mexico,an area to care for severe H1N1 cases on respiratory distress during the second H1N1-2009 outbreak, had to be habilitated.
View Article and Find Full Text PDFSalud Publica Mex
February 2012
Instituto Nacional de Enfermedades Respiratorias, México, DF, México.
Objective: Comparison of routine hospital indicators (consults at the Emergency Room (ER) and hospital admissions) during the 2009 pandemic of the influenza AH1N1 virus at the national referral hospital for respiratory diseases in Mexico City.
Material And Methods: The outbreak was from April to mid-May 2009 and two control periods were used:2009 (before and after the outbreak),and during April-May from 2007 and 2008.
Results: During the outbreak total consultation at the ER increased six times compared with the 2007-2008 control period and 11 times compared with the 2009 control period.
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