We describe a patient with advanced HIV infection and Balamuthia mandrillaris and Acanthamoeba amebic encephalitis with Toxoplasma gondii coinfection. A multidisciplinary effort and state-of-the-art diagnostic techniques were required for diagnosis. Our patient is the first reported case of an HIV-infected person with dual Balamuthia mandrillaris and Acanthamoeba amebic encephalitis with neurotoxoplasmosis coinfection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295102 | PMC |
| http://dx.doi.org/10.1128/JCM.06252-11 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Amoebae: beyond pathogens- exploring their benefits and future potential.
Front Cell Infect Microbiol
January 2025
Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational and Research Institute (RKMVERI), Kolkata, India.
Amoebae, fascinatingly diverse protists, showcase a dual nature that positions them as both friends and foes in our world. These organisms, defined by their distinctive pseudopodia, span a spectrum from harmful to helpful. On the darker side, species like pose serious health risks, causing intestinal and liver diseases, while the infamous "brain-eating" leads to fatal primary amoebic meningoencephalitis (PAM), with a daunting 97% mortality rate.
View Article and Find Full Text PDFYield of clinical metagenomics: insights from real-world practice for tissue infections.
EBioMedicine
December 2024
Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, PR China; Zhejiang Key Laboratory of Clinical in Vitro Diagnostic Techniques, Hangzhou, 310003, PR China; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, 310003, PR China. Electronic address:
Background: While metagenomic next-generation sequencing (mNGS) has been acknowledged as a valuable diagnostic tool for infections, its clinical validity and impact on patient management when using fresh tissue samples remains uncertain.
Methods: We conducted a retrospective cross-sectional study involving patients who underwent tissue mNGS at a tertiary hospital in China from February 2021 to February 2024, aiming to assess its ability to detect plausible pathogens and its clinical validity and impact.
Findings: A total of 520 mNGS results from 508 patients were analysed, detecting plausible pathogens in 302 (58.
Central Nervous System Vasculitis in an Immunocompetent Child: Case Report.
J Child Neurol
December 2024
Department of Neurology, University of California, Davis, Davis, CA, USA.
granulomatous amebic encephalitis is a rare disease that is associated with a high rate of mortality. Delays in diagnosis and treatment are common because of limited information on the organism in addition to its nonspecific clinical presentation. Prior reports have demonstrated that the encephalitis presents as multifocal lesions throughout the central nervous system with enhancement and edema.
View Article and Find Full Text PDF[Balamuthia mandrillaris amebic encephalitis: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Affiliated Hospital of Hebei University, Baoding071000, China.
Application of ventriculoscopy in granulomatous amoebic encephalitis: a case report in China and literature review.
Front Med (Lausanne)
November 2024
Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Article Synopsis
- A 58-year-old man with meningoencephalitis caused by a brain-eating amoeba died 33 days after symptoms began, highlighting the severity and limited treatment options for this condition.
- The study introduced ventriculoscopy as a surgical technique to observe and treat the extensive inflammatory response and manage complications like hydrocephalus and intracranial hypertension.
- Despite the patient's death from brainstem hemorrhage, the case emphasizes the importance of surgical interventions in diagnosing and managing amoebic encephalitis, calling for ongoing research to improve treatment strategies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!