Background: Obesity is a growing problem in the United States. Obesity alters the pharmacokinetic profiles of various drugs. Although there are guidelines for dose adjustments for many of the antibiotics commonly used in the emergency department (ED), they are seldom used.
Methods: This is an institutional review board-approved retrospective study at an American Society of Metabolic and Bariatric Surgery Center of Excellence and a level I trauma center with annual ED volumes of more than 80,000 visits. Data were retrospectively collected from ED pharmacy records during a 3-month period in 2008. Any first dose of cefepime, cefazolin, or ciprofloxacin administered in our ED to a patient recorded as both more than 100 kg and with a body mass index greater than 40 kg/m(2) was compared with our hospital guidelines and found to either adhere or not adhere to those guidelines.
Results: There were 1910 orders found to meet the study criteria: 775 orders for cefepime, 625 orders for cefazolin, and 510 orders for ciprofloxacin. Adherence rates for first dose of cefepime, cefazolin, and ciprofloxacin administered, respectively, were 8.0%, 3.0%, and 1.2%.
Conclusion: Emergency physicians frequently underdose cefepime, cefazolin, and ciprofloxacin in obese patients. Underdosing antimicrobials presents risk of treatment failure and may promote antimicrobial resistance. Education is necessary to improve early antibiotic administration to obese patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ajem.2011.05.027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of M1/M2 macrophage polarization in the pathogenesis of obesity-related kidney disease and related pathologies.
Front Immunol
January 2025
Laboratory of Immunohematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece.
Obesity is a rapidly growing health problem worldwide, affecting both adults and children and increasing the risk of chronic diseases such as type 2 diabetes, hypertension and cardiovascular disease (CVD). In addition, obesity is closely linked to chronic kidney disease (CKD) by either exacerbating diabetic complications or directly causing kidney damage. Obesity-related CKD is characterized by proteinuria, lipid accumulation, fibrosis and glomerulosclerosis, which can gradually impair kidney function.
View Article and Find Full Text PDFFrequency of undiagnosed hypertension among diabetic patients with micro vascular complications.
Pak J Med Sci
January 2025
Syed Khurram Shehzad, Department of Medicine, Lahore Medical and Dental College, Lahore, Pakistan.
Objectives: To determine the frequency of undiagnosed hypertension among the diabetic patients with micro vascular complications.
Method: This is a descriptive case series conducted at Department of Medicine, Ghurki Trust Teaching Hospital, in this six month stud which enrolled 213 patients between 18-60 years from March 28, 2021 to September 28, 2021, having diabetes with microvascular complications. These patients were not previously diagnosed as hypertensives.
Factors associated with eye disorders and diseases: A retrospective study.
Pak J Med Sci
January 2025
Olgun Goktas, Associate Professor, Uludag University Family Health Center, Nilufer, Bursa, Turkey.
Objective: To retrospectively identify the factors associated with eye disorders and diseases.
Methods: The retrospective study was carried out in Bursa Uludag University Family Health Center in Turkey between 1-30 September 2023. The data of individuals who were registered with the Family Health Center and whose eye disorders and diseases were known were evaluated retrospectively.
Association between Pre-pregnancy BMI and Pregnancy Outcomes in Women with Gestational Diabetes: A Retrospective Cohort Study.
Pak J Med Sci
January 2025
Lin Lin Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical, University, Fuzhou, Fujian, China.
Background & Objective: The specific influence of the pre-pregnancy body mass index (PPBMI) on women with gestational diabetes mellitus (GDM) is unclear. Our objective was to investigate how PPBMI categories affect pregnancy and neonatal outcomes in women with GDM.
Methods: A retrospective cohort study was conducted using data from patients attending the Fujian Maternity and Child Health Hospital (Fuzhou, China) from 2021 to 2023.
Data Mining of Infertility and Factors Influencing Its Development: A Finding From a Prospective Cohort Study of RaNCD in Iran.
Health Sci Rep
January 2025
Research Center for Environmental Determinants of Health (RCEDH), Health Institute Kermanshah University of Medical Sciences Kermanshah Iran.
Background And Aims: Infertility, as defined by the World Health Organization, is the inability to conceive after 12 months of regular, unprotected intercourse. This study aimed to identify factors influencing infertility by applying data mining techniques, specifically rule-mining methods, to analyze diverse patient data and uncover relevant insights. This approach involves a thorough analysis of patients' clinical characteristics, dietary habits, and overall conditions to identify complex patterns and relationships that may contribute to infertility.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!