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Ultrasound is a first-line and often preferred imaging modality in the diagnosis of acute appendicitis. When the appendix is not visualised during a dedicated appendix ultrasound study, patients may require a CT study, which uses ionising radiation, or undergo conservative clinical observation with the inherent risk of clinical deterioration, perforation and sepsis. Median baseline data, at our hospital imaging department, revealed a rate of combined normal and abnormal appendix visualisation of 34.

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Acquired Diaphragmatic Hernia and Intestinal Obstruction in a Child with Methylmalonic Acidemia Following Pediatric Liver Transplantation.

Transplant Proc

January 2025

Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. Electronic address:

Background: An acquired diaphragmatic hernia (ADH) is an uncommon event following pediatric liver transplantation. Pediatric liver transplantation proves effective in prolonging survival and improving quality of life for children with methylmalonic acidemia. Remarkably, there have been no previous reports documenting the occurrence of post-liver transplant ADH in patients diagnosed with methylmalonic acidemia.

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Transvestibular Chondrolarynoplasty-Experimental Study in Cadavers.

J Voice

January 2025

Universidade Federal de São Paulo - UNIFESP, 04023-062, São Paulo, São Paulo State, Brazil. Electronic address:

Background: The neck, and specifically the prominence of the thyroid cartilage, can be considered a marker of male gender, which is often unwanted by transgender women. Chondrolaryngoplasty is traditionally performed using an open transcervical approach, which, while effective, leaves visible scars that can compromise patient satisfaction. Recent advancements, such as the transoral endoscopic vestibular approach (TOEVA), have emerged as promising alternatives, eliminating external scars and improving esthetic outcomes.

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Artificial intelligence streamlines scientific discovery of drug-target interactions.

Br J Pharmacol

January 2025

Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug-target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by its high costs of experimental assays and low success rates.

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Background: Continuous spinal anesthesia (CSA) offers precise, prolonged neuraxial anesthesia suitable for high-risk patients. This technique minimizes hemodynamic instability but comes with notable challenges. Vigilant catheter management is crucial to avoid complications, including the risk of catheter retention.

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