In experiments on animals with choleperitonitis were signs of systemic inflammatory response syndrome, "rejuvenation" ofwbc as through the mobilization of neutrophils membrane pool and due to the activation of bone marrow reserve of granulocytes in response to the development of endogenous intoxication. The analysis of the results of the study also showed that animals with choleperitonitis have the change of the neutrophils functional state, which reflected in changes of their cytochemical profile, accompanied by a decrease in total activity and functional reserve of neutrophils, inhibition of nonspecific link of the immune system, manifested by a decrease of the neutrophils number, which are able to absorb and digest microbal cells.

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