Lamellar macular holes and macular pseudoholes are non-full-thickness defects of retinal tissue involving the anatomic fovea, thereby affecting central visual acuity. Non-full-thickness macular holes have been associated with myriad ocular conditions. Originally, lamellar macular holes were described as secondary to diabetic macular edema and macular pseudoholes as idiopathic. The pathogenesis of secondary non-full-thickness macular defects was recently confirmed by spectral-domain optical coherence tomography. These may be mistaken for macular hole lesions, despite careful clinical examination. Careful biomicroscopic examination with a contact lens and optical coherence tomography help to ensure accurate diagnosis. Surgical management with or without air or gas tamponade improves visual acuity and foveal morphology in most eyes.
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http://dx.doi.org/10.3928/15428877-20111208-01 | DOI Listing |
Am J Ophthalmol Case Rep
March 2025
University of Florida, Department of Ophthalmology, USA.
Purpose: Human amniotic membrane (hAM) grafts have been used to close persistent macular holes in recent years. The results from these surgeries are promising with improved closure rate and vision. However, there is lack of data for what happens to these membranes and how long the tissue should remain inside the patient's eyes.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India
A septuagenarian man presented with a visual acuity of hand motions and a large refractory macular hole (MH). We performed an autologous retinal transplant (ART) and covered the graft with fibrin glue without any endotamponade. The autograft was found to have dislocated from the MH when the patient was reviewed 1 week later.
View Article and Find Full Text PDFInt Ophthalmol
January 2025
Department of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Str., Ward 11, District 5, Ho Chi Minh City, 700000, Vietnam.
Purpose: This study evaluates the effectiveness of the inverted internal limiting membrane (ILM) flap technique during vitrectomy for treating macular hole-induced retinal detachment (MHRD) in high myopia patients, a challenging complication for vitreoretinal surgeons due to its treatment complexity.
Methods: We conducted a prospective study analyzing 92 eyes diagnosed with MHRD, all undergoing vitrectomy using the inverted ILM flap technique between February 2022 and September 2024. Successful surgery was defined as achieving retinal reattachment, macular hole closure, and improvement in visual acuity by the 12-month postoperative follow-up.
Vision (Basel)
January 2025
Department of Ophthalmology, King George's Medical University, Lucknow 226003, India.
Objectives: The goal was to study the ellipsoid zone (EZ) as a structural biomarker for final visual outcomes after pharmacological intervention in center-involving diabetic macular edema (DME) and surgical intervention for full-thickness macular holes (FTMHs).
Methods: This was a tertiary care center-based retrospective study. After sample size calculations, data from 64 consecutive cases were collected, with subjects aged between 40 and 60 years.
BMC Ophthalmol
January 2025
Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Background: Human anterior lens capsules (ALCs) have great potential in the treatment of multiple eye diseases, including corneal ulcers, glaucoma, age-related macular degeneration and macular holes. ALCs are also regarded as promising scaffolds for various ocular cells. Here, we investigated different decellularization methods for removing lens epithelial cells (LECs) that adhered to ALCs.
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