Lots of purified antigens have been obtained from crude antigens of Clonorchis sinensis. Some of them have applied to immunodiagnosis of clonorchiasis in laboratory. Here, we review purification methods, diagnostic efficacy and application prospect of purified antigens.
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Pharmaceutics
December 2024
Department of Medical Zoology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
: Clonorchiasis is a foodborne parasitic disease that can lead to severe biliary fibrosis and cholangiocarcinoma. While praziquantel (PZQ) is available for clonorchiasis treatment, it cannot revert the histopathological damage incurred through parasite-induced fibrosis. Curcumin (CUR) is an emerging experimental drug possessing anti-inflammatory and fibrosis-alleviating effects, thus signifying its potential as an anthelmintic drug.
View Article and Find Full Text PDFInfect Dis Poverty
January 2025
Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
Background: Clonorchiasis is an important foodborne parasitic disease in China caused by Clonorchis sinensis. Accurate and rapid diagnosis of this disease is vital for treatment and control. Traditional fecal examination methods, such as the Kato-Katz (KK) method, are labor-intensive, time-consuming, and have limited acceptance.
View Article and Find Full Text PDFMicrobiol Spectr
December 2024
Department of Cell Biology and Genetics, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China.
Unlabelled: remains a non-negligible global zoonosis, imposing serious socio-economic burdens in endemic regions. The interplay between gut microbiota and the host transcriptome is crucial for maintaining health; however, the impact of juvenile infection on these factors is still poorly understood. This study aimed to investigate their relationship and potential pathogenic mechanisms.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
December 2024
Department of Medical Statistics, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, 510080, Yuexiu District, Guangzhou, Guangdong Province, People's Republic of China.
Background: Cognition, behaviours and social environment are associated with Clonorchis sinensis infection, a prevalent liver fluke disease in China. This study aimed to use social cognitive theory (SCT) to investigate these three aspects and their interaction in an endemic area.
Methods: We conducted three semi-structured focus group discussions in Da'ao town, Jiangmen city, Guangdong Province, China.
Parasitol Res
December 2024
Department of Medical Sciences, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Clonorchiosis, a disease that develops following the consumption of raw freshwater fish that harbors Clonorchis sinensis metacercariae, seriously threatens the health of residents in endemic areas. We aimed to assess the level of awareness of liver fluke infections among infected residents and restaurant workers in liver fluke infection-endemic areas. To identify and provide a more realistic description of C.
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