The method of chemiluminescence immunoassay (CLIA) was adopted to detect the levels of hyaluronic acid (HA), laminin (LN), III procollagen (CP III), IV collagen (IV-C) in the sera of 102 cases of advanced schistosomiasis. The results showed that the levels of the 4 indexes of advanced schistosomiasis patients were significantly higher than those of healthy people. It is suggested that the application of CLIA to detect the related serum indexes in patients with advanced schistosomiasis is useful in the diagnosis of liver fibrosis.
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