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Function: require_once
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
Line: 249
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File: /var/www/html/index.php
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Function: _error_handler
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Function: insertAPISummary
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The Akt pathway is considered a pivotal player in regulating cell survival, growth, migration and angiogenesis. Disruption of normal Akt/PKB/PTEN signaling frequently occurs in numerous types of human cancers. Therefore, this signaling pathway is regarded as an important target for effective cancer therapeutic strategies. In the present study, methanol extracts from Scutellaria barbata (S. barbata) were determined to be Akt/protein kinase B inhibitory, after screening a panel of 40 traditional Chinese herbs with the Fast Activated Cell-based ELISA (FACE) assay. S. barbata extracts were found to suppress the phosphorylation levels of Akt. This inhibition was Akt kinase-specific as it had no effect on PI3K, the upstream kinase of Akt, whereas the levels of phosphorylated Bad and FHKR, the two downstream targets of Akt, changed as the levels of Akt changed. S. barbata extracts also exhibited cytotoxicity against LoVo and human umbilical vein endothelial cells (HUVECs). Furthermore, this extract inhibited the process of in vitro angiogenesis of HUVECs on Matrigel. S. barbata may be a suitable alternative source with which to isolate small molecules for use as Akt kinase inhibitors.
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http://dx.doi.org/10.3892/mmr.2011.694 | DOI Listing |
J Ovarian Res
December 2024
Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, 116044, China.
Background: Cisplatin (DDP) is one of the most effective anticancer drugs, commonly used to treat advanced ovarian cancer (OC). However, DDP has significant limitations of platinum-based drugs, including chemical resistance and high-dose toxic side effects. Traditional Chinese medicines (TCMs) often presented in the form of formula, in which the herb pair was the basic unit.
View Article and Find Full Text PDFFront Plant Sci
December 2024
Central Laboratory, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, China.
Introduction: D. Don is a widely cultivated Chinese herbal medicine known for its medicinal properties. However, differences in the spatial distribution of metabolites, accumulation patterns of flavonoids, and pharmacological activities between the aerial parts and roots of still remain unclear, posing challenges for its standardized cultivation and quality control.
View Article and Find Full Text PDFJ Integr Med
November 2024
Institute (College) of Integrative Medicine, Dalian Medical University, Dalian 116044, Liaoning Province, China. Electronic address:
Objective: Despite the combination of Scutellaria barbata D. Don and Scleromitrion diffusum (Willd.) R.
View Article and Find Full Text PDFFront Plant Sci
September 2024
School of Medical Laboratory, Shandong Second Medical University, Weifang, China.
Hemsl., known for its traditional use in Chinese herbal medicine, is valued for heat-clearing and detoxifying, promoting diuresis, reducing swelling, alleviating pain, and preventing miscarriage. Despite its historical use, comprehensive studies on pharmacophylogenetic analysis, including genetic and chemical profiles and the antimicrobial activity of are still lacking.
View Article and Find Full Text PDFMolecules
August 2024
School Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, China.
With the increasing global incidence and mortality rates of cancer, the development of novel anti-tumor drugs has become particularly urgent. D. Don, a perennial herb belonging to the genus Scutellaria in the family Lamiaceae, has aroused extensive attention for its medicinal value in recent years.
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