Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes.

Org Biomol Chem

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK OX1 3TA.

Published: February 2012

AI Article Synopsis

  • A variety of heterocycles such as thiazoles, imidazoles, and dimethoxyindoles have been synthesized from alkenes using a two-step process.
  • The initial alkenes are easily obtainable through established methods, offering a practical starting point.
  • This approach results in high yields and specific regioselectivity for the desired heterocycles.

Article Abstract

A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and regioselectivity.

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http://dx.doi.org/10.1039/c1ob06587dDOI Listing

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