Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/jid.2011.399 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deficiency in does not increase susceptibility of mice to pathogenesis by the mouse papillomavirus, MmuPV1.
J Virol
July 2024
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Article Synopsis
- Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder that leads to skin lesions caused by certain high-risk human papillomaviruses (HPVs) and can develop into squamous cell carcinoma (SCC).
- The disease primarily affects individuals with specific mutations in genes that are not fully understood, particularly in relation to their role in HPV infection.
- Studies using a mouse model show that while MmuPV1 (similar to β-HPVs) induces skin lesions and potential malignancy, the reaction in gene-null mice differs from that in EV patients, indicating complex interactions between the genes and HPV infection.
The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.
J Exp Med
September 2018
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY
Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of (encoding EVER1) or (EVER2) are selectively prone to disseminated skin lesions due to keratinocyte-tropic human β-papillomaviruses (β-HPVs), which lack E5 and E8. We describe EV patients homozygous for null mutations of the gene encoding calcium- and integrin-binding protein-1 (CIB1). CIB1 is strongly expressed in the skin and cultured keratinocytes of controls but not in those of patients.
View Article and Find Full Text PDFRegulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.
J Exp Med
January 2008
Unité de Génétique, Papillomavirus et Cancer Humain, Institut Pasteur, 75015 Paris, France.
Epidermodysplasia verruciformis (EV) is a genodermatosis associated with skin cancers that results from a selective susceptibility to related human papillomaviruses (EV HPV). Invalidating mutations in either of two genes (EVER1 and EVER2) with unknown functions cause most EV cases. We report that EVER1 and EVER2 proteins form a complex and interact with the zinc transporter 1 (ZnT-1), as shown by yeast two-hybrid screening, GST pull-down, and immunoprecipitation experiments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!