The 3 cases presented here involve 3 unusual and different complications of costal exostoses: spontaneous hemothorax, pneumothorax, and pericardial effusion. All of the cases presented with chest pain to the emergency department. Two of the cases have hereditary multiple exostoses. All but one of the patients required surgical intervention. Complications of costal exostoses are rare, but hemothorax, pneumothorax, and pericardial effusions can occur.
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http://dx.doi.org/10.1097/PEC.0b013e31823b45ca | DOI Listing |
J Orthop Case Rep
January 2025
Department of Orthopedics, Stanley Medical College, Chennai, Tamil Nadu, India.
Introduction: Osteochondroma is a bony lesion arising from the surface of the bone. It com-prises a large percentage of all benign bone tumors. A unique feature of this tumor is the conti-nuity of cortical and medullary components between the normal bony tissue and aberrant tissue of osteochondroma.
View Article and Find Full Text PDFMol Biotechnol
November 2024
Key Laboratory of Medical Biotechnology and Translational Medicine (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, 541199, China.
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disease. Genetic linkage analyses have identified that mutations in the exostosin glycosyltransferase (EXT)1 and EXT2 genes are linked to HME pathogenesis, with EXT1 mutation being the most frequent. The aim of this study was to generate a mice model with Ext1 gene editing to simulate human EXT1 mutation and investigate the genetic pathogenicity of Ext1 through phenotypic analyses.
View Article and Find Full Text PDFCureus
October 2024
Department of Orthopaedics, St. John's Medical College and Hospital, Bangalore, IND.
A 22-year-old man presented to us with back pain for four months, inability to walk, and weakness in both lower limbs. Clinical examination revealed multiple swellings in the body, motor weakness, paresthesia, and upper motor neuron signs. Both magnetic resonance imaging (MRI) and computed tomography (CT) revealed an abnormal bone mass protruding into the spinal canal from the posterior aspect of the ninth rib through the D9-D10 neural foramen.
View Article and Find Full Text PDFPediatr Pulmonol
January 2025
Department of Pediatrics, Carmel Medical Center, Haifa, Israel.
This article underscores the critical importance of thorough physical examinations and the need to investigate secondary causes in cases of refractory pneumothorax. The identification of hereditary multiple exostoses (HME) as the underlying condition highlights the necessity of considering rare etiologies, particularly in atypical presentations. While exostoses typically affect long bones, they can also involve the ribs and scapulae, leading to complications such as pneumothorax.
View Article and Find Full Text PDFPathol Oncol Res
May 2024
Department of Medical Genetics, Clinical Center, Medical School, University of Pécs, Pécs, Hungary.
Gardner syndrome is a rare genetic cancer predisposition disorder characterized by intestinal polyposis, multiple osteomas, and soft and hard tissue tumors. Dental anomalies are present in approximately 30%-70% of patients with Gardner syndrome and can be discovered during routine dental examinations. However, sometimes the diagnosis is challenging due to the high clinical variability and incomplete clinical picture.
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