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http://dx.doi.org/10.1038/npp.2011.116 | DOI Listing |
J Rural Health
January 2025
Department of Informatics and Health Data Science, Miller School of Medicine, University of Miami, Miami, USA.
Neurosci Insights
December 2024
Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA.
Mitochondrial dysfunction plays a pivotal role in the progression of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's, and Parkinson's disease. Recent discoveries have highlighted the involvement of DNA damage and repair processes, particularly mitochondrial DNA (mtDNA) damage, in these conditions. This commentary reflects on our recent findings, demonstrating the RNA/DNA binding protein fused in sarcoma (FUS)'s crucial role in maintaining mtDNA integrity through interactions with mitochondrial DNA ligase IIIα (mtLig3).
View Article and Find Full Text PDFBiol Sex Differ
November 2024
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Circ Cardiovasc Qual Outcomes
December 2024
Department of Internal Medicine, Section of Cardiovascular Medicine (V.S., R.K.), Yale School of Medicine, New Haven, CT.
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