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| http://dx.doi.org/10.2215/CJN.10281011 | DOI Listing |
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Clinical significance of small dense low-density lipoprotein cholesterol measurement in type 2 diabetes.
J Diabetes Investig
January 2025
Diabetes Center, Ebina General Hospital, Ebina City, Kanagawa, Japan.
Low-density lipoprotein cholesterol (LDL-C) is known to be a causal substance of atherosclerosis, but its usefulness as a predictive biomarker for atherosclerotic cardiovascular disease (ASCVD) is limited. In patients with type 2 diabetes (T2D), LDL-C concentrations do not markedly increase, while triglycerides (TG) concentrations are usually elevated. Although TG is associated with ASCVD risk, they do not play a direct role in the formation of atheromatous plaques.
View Article and Find Full Text PDFRefinement of a Published Gene-Physical Activity Interaction Impacting HDL-Cholesterol: Role of Sex and Lipoprotein Subfractions.
Genet Epidemiol
January 2025
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Large-scale gene-environment interaction (GxE) discovery efforts often involve analytical compromises for the sake of data harmonization and statistical power. Refinement of exposures, covariates, outcomes, and population subsets may be helpful to establish often-elusive replication and evaluate potential clinical utility. Here, we used additional datasets, an expanded set of statistical models, and interrogation of lipoprotein metabolism via nuclear magnetic resonance (NMR)-based lipoprotein subfractions to refine a previously discovered GxE modifying the relationship between physical activity (PA) and HDL-cholesterol (HDL-C).
View Article and Find Full Text PDFHypertension and High-Density Lipoprotein Cholesterol: A Narrative Review.
Curr Hypertens Rev
December 2024
Hypertension Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Hypertension remains the primary driver of Cardiovascular Diseases (CVDs) and mortality. Dyslipidaemia is a common risk factor for CVDs in hypertensive patients, and their coexistence significantly increases the risk of CVDs. Furthermore, epidemiologic studies indicate that there are U-shaped curves between cholesterol levels of HDL-C and CVDs-related mortality in patients with hypertension, in which CVDs are paradoxically increased in those with elevated HDLC levels.
View Article and Find Full Text PDFPer- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women.
Environ Health
December 2024
Department of Nutrition, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Background: Existing evidence for associations of per- and polyfluoroalkyl substances (PFASs) with blood lipids, lipoproteins and apolipoproteins (apo), and coronary heart disease (CHD) risk is limited and inconsistent. This study aims to explore associations between plasma PFASs, blood lipoprotein subspecies defined by apolipoproteins, and CHD risk.
Methods: A case-control study of CHD was conducted in the Health Professionals Follow-Up Study (HPFS) and Nurses' Health Study (NHS).
Nuclear Magnetic Resonance Analysis Implicates Sex-Specific Dysregulation of the Blood Lipids in Alzheimer's Disease: A Retrospective Health-Controlled Study.
Psychiatry Investig
November 2024
Institute of Mental Health, Tianjin Mental Health Center, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China.
Objective: The aging demographic landscape worldwide portends a heightened prevalence of neurodegenerative disorders. Foremost among these is Alzheimer's disease (AD), the foremost cause of dementia in older adults. The shortage of efficacious therapies and early diagnostic indicators underscores the imperative to identify non-invasive biomarkers for early detection and disease monitoring.
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