Magnetic nanoparticles (MNPs) have been studied widely as a powerful diagnostic probe and therapeutic agent for biomedical applications. In recent years, they are also found to be sensitive to magnetoresistive (MR) devices and MNP-MR biochips are predicted to be more affordable, portable and sensitive than the conventional optical detection methods. In this MNP-MR biochip design, MNP probes are required to have high magnetic moment, high susceptibility, and be target-specific. This review summarizes recent advances in chemical syntheses and functionalization of MNPs with controlled magnetic properties for sensitive MR detection and for bio-sensing applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/TNB.2011.2176509 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format.
Nanomaterials (Basel)
December 2024
Personalized Medicine Centre, Almazov National Medical Research Centre, Akkuratova Str. 2, 197341 St. Petersburg, Russia.
This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing personalized adjustments, and highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments and assess drug efficacy and dosage in a controlled setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) and carboxymethyl dextran coated superparamagnetic nanoparticles (CD-SPIONs), and evaluated their transport properties in microfluidic systems and porous media. The original uncoated mMNPs of bimodal size distribution and the narrow size distribution of the fractions (23 nm and 106 nm by radii) were demonstrated to agglomerate in magnetically driven microfluidic flow, forming a stable stationary web consisting of magnetic fibers within 30 min.
View Article and Find Full Text PDFCarbapenem-Resistant Adherence to Magnetic Nanoparticles.
Nanomaterials (Basel)
December 2024
Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI 48824, USA.
Carbapenem-resistant (CRE) is an emerging global concern. Specifically, carbapenemase-producing (CP) strains in CRE have recently been found in clinical, environmental, and food samples worldwide, causing many hospitalizations and deaths. Their rapid identification and characterization are paramount in control, management options, and treatment choices.
View Article and Find Full Text PDFElectrochemical Method for the Design of New Possible Gadolinium-Based Contrast Agents.
Nanomaterials (Basel)
December 2024
Laboratory of Applied Electrochemistry, Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi, 19, 20133 Milan, Italy.
Magnetic resonance imaging (MRI) is a technique that employs strong magnetic fields and radio frequencies to generate detailed images of the body's interior. In oncology patients, gadolinium-based contrast agents (GBCAs) are frequently administered to enhance the visualization of tumors. Those contrast agents are gadolinium chelates, characterized by high stability that prevents the release of the toxic gadolinium ion into the body.
View Article and Find Full Text PDFCharacteristics and Antitumor Activity of Doxorubicin-Loaded Multifunctional Iron Oxide Nanoparticles in MEC1 and RM1 Cell Lines.
J Funct Biomater
December 2024
Division of Immunology and Microbiology, Iv. Javakhishvili Tbilisi State University, 1, Ilia Tchavchavadze Ave., 0179 Tbilisi, Georgia.
The rapid progress in nanotechnology has introduced multifunctional iron oxide nanoparticles as promising agents in cancer treatment. This research focused on the synthesis and assessment of citric-acid-coated, folic-acid-conjugated nanoparticles loaded with doxorubicin, evaluating their therapeutic potential in tumor models. An advanced automated continuous technology line (CTL) utilizing a controlled co-precipitation method was employed to produce highly dispersive, multifunctional nanofluids with a narrow size distribution.
View Article and Find Full Text PDFNew Trends of Personalized Medicine in the Management of Abdominal Aortic Aneurysm: A Review.
J Pers Med
December 2024
Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL 32224, USA.
Abdominal aortic aneurysm (AAA) is a significant vascular condition characterized by the dilation of the abdominal aorta, presenting a substantial risk of rupture and associated high mortality rates. Current management strategies primarily rely on aneurysm diameter and growth rates to predict rupture risk and determine the timing of surgical intervention. However, this approach has limitations, as ruptures can occur in smaller AAAs below surgical thresholds, and many large AAAs remain stable without intervention.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!