This article contains analyses of etiopathogenezis clinic treatment data provided by different literature on diabetic rethinopathy. Diabetic rethinopathy is the main reason for blindness and lost vision. The article highlights modern views on ethiopathogenezis clinic and treatment of diabetic retinopathy. The paper considers the methods of laser coagulation, intravitreal injection of avastin in vitreus body and for deep stages of diabetic rethinopathy - application of surgery as advanced means for treatment.
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Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats.
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National Colorectal Disease CenterNanjing Hospital of Chinese Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, Jiangsu, People's Republic of China.
Background: Complex perianal fistulas, challenging to treat and prone to recurrence, often require surgical intervention that may cause fecal incontinence and lower quality of life due to large surgical wounds and potential sphincter damage. Human umbilical cord-derived MSCs (hUC-MSCs) and their exosomes (hUCMSCs-Exo) may promote wound healing.
Methods: This study assessed the efficacy, mechanisms, and safety of these exosomes in treating complex perianal fistulas in SD rats.
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Diabetes is associated with excessive inflammation, which negatively impacts the fracture healing process and delays bone repair. Previously, growing evidence indicated that activation of the nod-like receptor (NLR) family, such as nod-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome induces a vicious cycle of chronic low-grade inflammatory responses in diabetic fracture. Here, we describe the synthesis of a bone adhesive hydrogel that can be locally injected into the fracture site and releases a natural inhibitor of NLRP3 (rutin) in response to pathological cue reactive oxygen species activity (ROS).
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