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Does pseudohypoaldosteronism mask the diagnosis of congenital adrenal hyperplasia? | LitMetric

Does pseudohypoaldosteronism mask the diagnosis of congenital adrenal hyperplasia?

J Clin Res Pediatr Endocrinol

Dr. Sami Ulus Obstetrics and Gynecology, Pediatric Health and Disease Training and Research Hospital, Clinics of Pediatric Endocrinology, Ankara, Turkey.

Published: April 2012

AI Article Synopsis

  • Some newborns initially diagnosed with CAH, experiencing vomiting and poor feeding, may actually have pseudohypoaldosteronism (PHA) instead.
  • The text discusses cases where high aldosterone levels initially led to considering PHA, but further testing revealed that these patients actually had SL-CAH.

Article Abstract

Hyponatremia and hyperpotassemia occurring in the first few weeks of life primarily indicate aldosterone deficiency due to salt-losing congenital adrenal hyperplasia (SL-CAH), while mineralocorticoid deficiency and insensitivity are the main causes of hyponatremia and hyperpotassemia in older infants. Some patients who present with vomiting and poor sucking, who have hyponatremia and hyperpotassemia and are initially diagnosed as CAH, during follow-up, are found to suffer from pseudohypoaldosteronism (PHA). This situation has been reported several times before. The cases described here represent the opposite situation: they presented with hyponatremia and hyperpotassemia, thus PHA was considered as aldosterone levels were very high, but subsequent investigation and genetic analysis led to the diagnosis of SL-CAH.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245498PMC
http://dx.doi.org/10.4274/jcrpe.369DOI Listing

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