Objective: The aim of this study is to describe six cases with spontaneous resorption of sequestrated intervertebral disc herniation observed using magnetic resonance imaging. In addition, the possible mechanisms, predictive factors of spontaneous disappearance of the sequestrated disc herniation, and the proper surgical timing were discussed and reviewed in literature.
Methods: All the studied cases experienced acute radicular pain due to sequestrated intervertebral disc herniation; they refused surgery and were treated conservatively, and they were followed up neurologically and radiologically in the outpatient clinic in regular visits.
Results: The studied cases included five cases with lumbar disc herniation (three at level L4-5 and two at level L5-S1) and one case with cervical disc herniation at level C5-6. All patients recovered from their radicular pain within 3 to 6 weeks, and it was correlated with resorption of their sequestrated intervertebral disc herniation as documented in their follow-up magnetic resonance imaging at 4 to 9 months.
Conclusions: We found that sequestrated disc herniation has potential for regression, which can be clearly demonstrated by magnetic resonance imaging, because of having higher water content, and therefore, may regress through both dehydration and inflammation-mediated resorption. We suggest conservative treatment in the initial course of the sequestrated type of disc herniation for at least 2 months before recommending surgical intervention unless severe neurologic deterioration takes place.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.wneu.2011.04.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs.
J Vet Intern Med
January 2025
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Background: Clinical characteristics of cervical hydrated nucleus pulposus extrusion (HNPE) in dogs compared to other causes of cervical myelopathy are not well described.
Hypothesis/objectives: To evaluate for clinical characteristics and mechanical ventilation likelihood associated with HNPE compared to other causes of cervical myelopathy.
Animals: Three hundred seventy-seven client-owned dogs from 2010 to 2022.
Comparison of Unilateral and Bilateral Transforaminal Epidural Steroid Injections in Unilateral Lumbar Disc Herniation: A Randomized Controlled Trial.
J Clin Med
December 2024
Department of Anesthesiology and Reanimation, School of Medicine, Ankara University, 06100 Ankara, Turkey.
To compare the efficiency of unilateral and bilateral transforaminal epidural steroid injections (TFESI) in patients with unilateral lumbar disc herniation (LDH). In this prospective randomized single-blinded study, patients with unilateral LDH were randomly divided into two groups: A unilateral TFESI group; and a bilateral TFESI group. The severity of pain and disability were assessed with the Numeric Rating Scale (NRS-11) and Oswestry Disability Index (ODI) at baseline, 1 week, 1 month, and 3 months after interventions.
View Article and Find Full Text PDFDevelopment and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion.
J Orthop Surg Res
January 2025
Hebei Orthopaedic Research Institute, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P.R. China.
Objective: The postoperative recovery of patients with lumbar disc herniation (LDH) requires further study. This study aimed to establish and validate a predictive model for functional recovery in patients with LDH and explore associated risk factors.
Method: Patients with LDH undergoing PLIF admitted from January 1, 2018 to December 31, 2022 were included, and patient data were prospectively collected through follow-up.
Patient-specific spine digital twins: a computational characterization of the idiopathic scoliosis.
J Orthop Surg Res
January 2025
Biomedical Engineering Department, Universidad de los Andes, Bogotá, Colombia.
Article Synopsis
- Scoliosis is identified through Cobb's angle, and this study aims to create a digital twin of the spine to analyze biomechanical stresses and disc degeneration related to idiopathic scoliosis using patient-specific data.
- A 3D computational model was developed that modifies intervertebral disc properties based on radiological measurements, validated by comparing with patient images; finite element analysis clarified the impact of deformity on spinal biomechanics.
- The results showed that the model accurately represented thoracic scoliosis and revealed that disc strain increases near the apex, with "type-C" curves at higher risk for herniation compared to "type-S," thereby enhancing understanding of scoliosis and aiding in treatment planning.
Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease.
J Orthop Surg Res
January 2025
Department of Orthopaedics, Qilu Hospital of Shandong University, No.107, Wenhuaxi Road, Lixia District, Jinan, Shandong Province, 250012, China.
Background: Ferroptosis was involved in the pathogenesis of intervertebral disc degeneration (IVDD). However, the exact mechanism of IVDD associated with ferroptosis still required deeper studies.
Method: The differentially expressed genes (DEGs) in rat lumbar disc tissue between the control and IVDD group treated with IL-1β were detected by RNA sequencing (RNA-seq).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!