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Anxiety disorders are among the most common mental illnesses, with huge attendant suffering. Current treatments are not universally effective, suggesting that a deeper understanding of the causes of anxiety is needed. To understand anxiety disorders better, it is first necessary to understand the normal anxiety response. This entails considering its evolutionary function as well as the mechanisms underlying it. We argue that the function of the human anxiety response, and homologues in other species, is to prepare the individual to detect and deal with threats. We use a signal detection framework to show that the threshold for expressing the anxiety response ought to vary with the probability of threats occurring, and the individual's vulnerability to them if they do occur. These predictions are consistent with major patterns in the epidemiology of anxiety. Implications for research and treatment are discussed.
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http://dx.doi.org/10.1177/070674371105601202 | DOI Listing |
BMJ Open
March 2025
Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Background: Nearly half of individuals who sustain orthopaedic trauma develop chronic pain and experience significant levels of depression and anxiety. Emotional awareness and expression therapy (EAET) is a newly developed psychological intervention designed to treat chronic pain by helping patients process psychological trauma and conflict to reduce pain. The purpose of this study is to examine the feasibility of delivering EAET to individuals who sustained traumatic orthopaedic injuries requiring surgery and who have chronic pain 6 months after hospital discharge.
View Article and Find Full Text PDFCommun Psychol
March 2025
Behavioural Science and Insights Unit, UK Health Security Agency, Salisbury, UK.
This pre-registered systematic review aimed to examine whether online support groups affect the health and wellbeing of individuals with a chronic condition, and what mechanisms may influence such effects. In September 2024, literature searches were conducted across electronic databases (Medline, Embase, PsycInfo, Web of Science and Google Scholar), pre-publication websites (MedRxiv and PsyArXiv) and grey literature websites. Qualitative and quantitative studies were included if they explored the impact of online support groups on the health and wellbeing outcomes of individuals with a chronic condition.
View Article and Find Full Text PDFNPJ Sci Learn
March 2025
Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Using spatial mapping processes to discriminate between threat and safety is crucial for survival. Little is known why some fail to discriminate during contextual conditioning. We used a virtual reality (VR) contextual conditioning paradigm to elucidate the effects of state and trait anxiety on contextual threat learning.
View Article and Find Full Text PDFBrain Res Bull
March 2025
Laboratory of Neuroscience, Department of Psychology, University of Oviedo, Oviedo, Spain; Institute of Neurosciences of the Principality of Asturias (INEUROPA), Oviedo, Spain; Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain. Electronic address:
The global rise in obesity and poor dietary habits, particularly the consumption of high-fat, high-sucrose (HFS) diets, is a growing public health concern. These diets, especially when consumed during critical developmental periods, such as gestation and early life, are linked to long-term consequences on both physical and mental health. Early exposure to obesogenic diets has been shown to disrupts brain function and increases the risk of anxiety, depression, and additional emotional disorders.
View Article and Find Full Text PDFBehav Brain Res
March 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:
Objective: The treatment of neuropathic pain is crucial, as it not only alleviates physical discomfort but also reduces anxiety associated with pain, ultimately enhancing the quality of life for affected individuals. This study investigates the protective effects of hydro-alcoholic extracts from Eryngium billardieri (Er) and Urtica dioica (Ur) on neuropathic pain and anxiety responses in an animal model.
Methods: 40 male Wistar rats were used to investigate neuropathy induced by the chronic constriction injury (CCI) model.
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