Imogolite is one of the clay minerals contained in volcanic ash soils. The novel hybrid hydrogels were prepared from imogolite nanofibers and DNA by utilizing strong interaction between the aluminol groups on imogolite surface and phosphate groups of DNA. The hybrid hydrogels of imogolite and DNA were prepared in various feed ratios, and their physicochemical properties and molecular aggregation states were investigated in both dispersion and gel states. The maximum DNA content in the hybrid gels was shown in equivalent molar ratio of imogolite and DNA. The physical properties of the hybrid gels were changed by varying DNA blend ratios. In the dispersion state, the hybrid gels showed a fibrous structure of imogolite, whereas a continuous network structure was observed in pure imogolite, indicating that the hybrid with DNA enhanced the dispersion of imogolite. In the gel state, DNA and imogolite nanofibers formed a 3D network structure.
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http://dx.doi.org/10.1021/bm201616m | DOI Listing |
J Biomed Mater Res A
January 2025
Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta, Canada.
Bentonite clay nanoparticles assume a pivotal role in 3D bioprinting and tissue engineering by augmenting the mechanical rigidity and biological efficacy of hydrogels. In this investigation, Span80 was employed as a surfactant to facilitate the synthesis of uniformly sized bentonite nanoparticles measuring approximately 700 nm in diameter. The resultant hybrid hydrogel displaced a marked increase in compressive modulus, achieving a peak value of 17.
View Article and Find Full Text PDFBiomacromolecules
January 2025
Institute of Surface Engineering (IOM), Permoserstraße 15, 04318 Leipzig, Germany.
Hybrid hydrogels are promising for wound dressing, tissue engineering, and drug delivery due to their exceptional biocompatibility and mechanical stability. This study synthesized hybrid hydrogels for photodynamic therapy using electron beam-initiated polymerization with varying PEGDA/gelatin ratios and irradiation doses to evaluate their effectiveness as uptake and release systems for five photosensitizers. Toluidine blue, O (TBO); methylene blue (MB); eosin, Y; indocyanine, green; and sodium meso-tetraphenylporphine-4,4',4″,4‴-tetrasulfonate were studied for their uptake and release dynamics in relation to their structural properties and the hydrogels' composition.
View Article and Find Full Text PDFSoft Matter
January 2025
Department of Physical Chemistry, Complutense University of Madrid, Av. Complutense s/n, 28040 Madrid, Spain.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
January 2025
Department of Life Science, SSSUHE, Kalaburagi, Karnataka, India.
The aim of this study is to explore and evaluate recent innovations in drug delivery systems (DDS) for biologics, focusing on enhancing stability and targeted delivery to improve the efficacy and safety of next-generation therapeutics. The most recent developments in a variety of DDS, such as nanoparticles, microneedles, hydrogels, and biodegradable polymers, were examined in depth. Information from peer-audited diaries, clinical preliminaries, and mechanical reports were blended to survey the presentation of these frameworks concerning dependability, designated conveyance, patient consistence, and controlled discharge.
View Article and Find Full Text PDFLangmuir
January 2025
Dipartimento di Fisica e Chimica - Emilio Segré, Università degli Studi di Palermo, Viale delle Scienze ed. 18, 90128 Palermo, Italy.
Amyloid fibrils have recently emerged as promising building blocks for functional materials due to their exceptional physicochemical stability and adaptable properties. These protein-based structures can be functionalized to create hybrid materials with a diverse range of applications. Here we report a simple eco-friendly protocol for generating amyloid fibrils from hen egg white lysozyme decorated with gold nanoparticles that can self-assemble in a hydrogel.
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