AI Article Synopsis
- The study presents a supramolecular double hydrophilic block copolymer (DHBC) formed through cucurbit[8]uril (CB[8]) complexation, which can self-assemble into micelles.
- The DHBC is engineered to respond to various external stimuli, including temperature changes, pH levels, and the presence of competitive guest molecules.
- The system demonstrated effective encapsulation and controlled release of the chemotherapy drug doxorubicin (DOX), significantly reducing the viability of HeLa cancer cells when triggered.
Article Abstract
The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAEMA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli-responsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.
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| http://dx.doi.org/10.1021/bm201588m | DOI Listing |
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