AI Article Synopsis
- - A 24-year-old woman developed hemorrhagic vesicles on her legs after taking the weight-loss drug sibutramine for 3 months.
- - A skin biopsy revealed leukocytoclastic vasculitis with eosinophilic infiltration, and her symptoms improved after stopping the drug.
- - The skin lesions returned when she was re-exposed to sibutramine for 2 weeks, marking the first reported case of necrotizing vasculitis linked to this medication.
Article Abstract
A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil®, Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months later the skin lesions recurred on other sites on the lower extremities when the patient was rechallenged with the same drug for 2 weeks. Herein, we report the first case of necrotizing vasculitis induced by sibutramine.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229957 | PMC |
| http://dx.doi.org/10.5021/ad.2011.23.4.544 | DOI Listing |
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