Cutaneous leiomyosarcoma is a relatively uncommon tumor that accounts for 7% of all soft tissue sarcomas. It occurs more frequently in males between 50-70 years and only 10-15% of cases are located on the trunk. Radiotherapy and previous trauma have been implied as risk factors. We report the case of a 57 year-old male with an eight-month history of a hard painless erythematous-violaceous tumor on the presternal region. Histopathology evidenced a malignant spindle cell tumor, "cigar" shaped, with pleomorphic nuclei and a high mitotic index that occupied the entire dermal thickness. Immunohistochemical staining of the tumor cells was positive for smooth muscle actin, desmin and vimentin and negative for S-100 protein and pan-cytokeratin, which supported the diagnosis of dermal leiomyosarcoma. Radical surgery was performed to remove the tumor.
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http://dx.doi.org/10.1590/s0365-05962011000500021 | DOI Listing |
Arch Dermatol Res
December 2024
Department of Dermatology, University of Nebraska Medical Center, Omaha, NE, USA.
Arch Dermatol Res
December 2024
Department of Dermatology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
J Am Acad Dermatol
November 2024
Department of Dermatology, University of California Davis Health, Sacramento, California; Touro University California College of Osteopathic Medicine, Vallejo, California; University of Florida College of Medicine, Maples Center for Forensic Medicine, Gainesville, Florida. Electronic address:
J Am Acad Dermatol
November 2024
American Medical Program, Tel Aviv University, Tel Aviv, Israel.
J Am Acad Dermatol
October 2024
Department of Plastic Surgery and Burns Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.
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