The annual incidence of invasive Kingella kingae infection in children younger than 4 years of age was significantly higher in westernized Jews than in indigent Bedouins living side by side in southern Israel (12.21/100,000 and 5.83/100,000, respectively, (P < 0.05). One K. kingae clone was overrepresented among isolates from Jewish children, suggesting that differences in bacterial pathogenicity may contribute to the morbidity excess detected in this population group.
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http://dx.doi.org/10.1097/INF.0b013e318240cf8a | DOI Listing |
J Child Orthop
January 2025
Great Ormond St Hospital for Children, London, UK.
Biochimie
December 2024
Institute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20, Prague, Czech Republic. Electronic address:
Kingella kingae, an emerging pediatric pathogen, secretes the pore-forming toxin RtxA, which has been implicated in the development of various invasive infections. RtxA is synthesized as a protoxin (proRtxA), which gains its biological activity by fatty acylation of two lysine residues (K558 and K689) by the acyltransferase RtxC. The low acylation level of RtxA at K558 (2-23 %) suggests that the complete acylation at K689 is crucial for toxin activity.
View Article and Find Full Text PDFInt J Surg Case Rep
January 2025
Trauma and Orthopedics Department B, Mohammed VI University Hospital, Marrakesh, Morocco; Laboratory of Clinical and Epidemiological Research in Bone and Joint Pathology, Marrakesh, Morocco.
Introduction: Septic arthritis is a severe joint infection that can cause permanent damage if not promptly treated. Although the shoulder is an uncommon site for this condition, Kingella kingae, typically associated with pediatric infections, can occasionally be a causative agent. Postpartum septic arthritis is rare, making this case particularly unique.
View Article and Find Full Text PDFMicroorganisms
January 2024
Pediatric Cardiology Unit, Department of Woman, Child, and Adolescent Medicine, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Infective endocarditis due to is a rare but serious invasive infection that occurs mostly in children. Recent advances in nucleic acid amplification testing as well as in cardiac imaging have enabled more accurate diagnosis. A good understanding of the epidemiology and virulence factors remains crucial to guide the therapeutic approach.
View Article and Find Full Text PDFFront Oncol
December 2023
University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Head and neck cancer (HNC) is the sixth most common type of cancer, with more than half a million new cases annually. This review focuses on the role of oral dysbiosis and HPV infection in HNCs, presenting the involved taxons, molecular effectors and pathways, as well as the HPV-associated particularities of genetic and epigenetic changes and of the tumor microenvironment occurred in different stages of tumor development. Oral dysbiosis is associated with the evolution of HNCs, through multiple mechanisms such as inflammation, genotoxins release, modulation of the innate and acquired immune response, carcinogens and anticarcinogens production, generation of oxidative stress, induction of mutations.
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