The concentrations of the thyrotrophic hormone (TTH). bound thyroxine (T4), free thyroxine (FT4), and triiodothyronine (T3) were measured by RIA in the blood of 10 test subjects during a 370-day head-down tilt study and a 250-day recovery period after it. The concentrations of TTH, FT4, and T3 decreased during bed rest and did not return to norm during recovery. It can be assumed that during bed rest TTH stimulation of the thyroid gland declines, which can act as an adaptive response to lower physical load.

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