AI Article Synopsis
- Stress pathways, particularly the unfolded protein response (UPR), help maintain balance in the endoplasmic reticulum (ER) under stress by activating specific gene targets.
- A unique genetic approach has demonstrated that the UPR can correct various dysfunctions that would be harmful without its intervention.
- Transcriptional profiling indicates that the UPR can adapt its response based on the type and intensity of stress, highlighting its crucial role in maintaining cellular stability.
Article Abstract
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the unfolded protein response (UPR), is responsible for maintaining endoplasmic reticulum (ER) homeostasis. The highly conserved Ire1 branch regulates hundreds of gene targets by activating a UPR-specific transcription factor. To understand how the UPR manages ER stress, a unique genetic approach was applied to reveal how the system corrects disequilibria. The data show that the UPR can address a wide range of dysfunctions that are otherwise lethal if not for its intervention. Transcriptional profiling of stress-alleviated cells shows that the program can be modulated, not just in signal amplitude, but also through differential target gene expression depending on the stress. The breadth of the functions mitigated by the UPR further supports its role as a major mechanism maintaining systems robustness.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251055 | PMC |
| http://dx.doi.org/10.1073/pnas.1117184109 | DOI Listing |
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