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Neighborhood Socioeconomic Status and Cardiovascular Events in Adults With CKD: The CRIC Study.
Kidney Med
November 2024
Department of Medicine, University of Illinois Chicago, Chicago, IL.
Rationale & Objective: In the general population, neighborhood socioeconomic status (SES) has been found to be associated with cardiovascular risk, but this relationship has not been well studied among patients with chronic kidney disease (CKD). This study seeked to evaluate the association between neighborhood SES and cardiovascular outcomes in a CKD cohort.
Study Design: Multicenter prospective cohort.
Relationship Between Quality of Life, Perceived Stress, and Disease Characteristics in Patients With Ulcerative Colitis in Al-Madinah.
Cureus
December 2024
Internal Medicine, Al Rayan College, Madina, SAU.
Background Ulcerative colitis (UC) is a common chronic disease. Perceived stress is one of the risk factors that stimulate UC activity. Long-term clinical suffering negatively alters the health-related quality of life (HRQOL).
View Article and Find Full Text PDFEnvironmental risk assessment methodology for urban tropical lagoons based on feasible lines of evidence under limited resources conditions: Jacarepaguá Lagoon/Brazil.
Ecotoxicology
January 2025
Department Sanitary and Environmental Engineering, Rio de Janeiro State University-UERJ, Rio de Janeiro, CEP, Brazil.
Determining environmental risk levels posed to different urban lagoon can provide an important overview regarding the relative severity of the environmental degradation of these ecosystems, increasing the risks visibility, which can be used as an important decision-making tool to prioritize investments. Jacarepaguá Lagoon (JPAL) is part of a coastal lagoon system comprising four interconnected lagoons in Rio de Janeiro city, Southeastern Brazil. Real estate speculation and insufficient sanitation infrastructure resulted in untreated sewage discharge into this ecologically sensitive lagoon system.
View Article and Find Full Text PDF90 Days to Predict a Year: A Bayesian Journey into Medication Adherence Post Myocardial Infarction.
Eur J Prev Cardiol
January 2025
Inserm U1094, IRD UMR270, Univ. Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, OmegaHealth, Limoges, France.
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease.
Immunity
January 2025
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia. Electronic address:
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a large disease-causing clone. A method for quantifying low-affinity binding revealed recurring antibody variable domain combinations created by V(D)J recombination that bound self-immunoglobulin G (IgG) but not viral E2 antigen.
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