AI Article Synopsis
- * The study aimed to understand how this chiral inversion occurs, finding that S-MA was converted to R-MA in rat liver cells, but remained unchanged in other environments like buffers and specific cell lines.
- * The research suggests that the process of this inversion may involve the breakdown of a derivative of S-MA (S-MA-CoA), with similarities to the metabolism of certain drugs known as 2-arylpropionic acids.
Article Abstract
Mandelic acid (MA) is generally used as a biological indicator of occupational exposure to styrene, which is classified as a class of hazardous environmental pollutants. It was found to undergo one-directional chiral inversion (S-MA to R-MA) in Wistar and Sprague-Dawley rats in vivo. This study was aimed to explore the metabolic mechanism of chiral inversion of S-MA in vitro. S-MA was converted to R-MA in rat hepatocytes, whereas MA enantiomers remained unchanged in acidic and neutral phosphate buffers, HepG2 cells, and intestinal flora. In addition, the synthesized S-MA-CoA thioester was rapidly racemized and hydrolyzed to R-MA by rat liver homogenate and S9, cytosolic and mitochondrial fractions. The data suggest that chiral inversion of S-MA may involve the hydrolysis of S-MA-CoA, and its metabolic mechanism could be the same as that of 2-arylpropionic acid (2-APA) drugs.
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| http://dx.doi.org/10.1002/chir.21031 | DOI Listing |
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