AI Article Synopsis
- This study explores how CRM197-grafted polybutylcyanoacrylate (PBCA) nanoparticles can effectively deliver zidovudine (AZT) through the blood-brain barrier.
- The AZT-loaded nanoparticles were found to have a uniform size, a spherical shape, and a unique hexagonal lattice structure when analyzed.
- Results showed that smaller nanoparticles and higher amounts of CRM197 enhanced both the efficiency of AZT loading and its ability to permeate the blood-brain barrier.
Article Abstract
This study investigates the capability of CRM197-grafted polybutylcyanoacrylate (PBCA) nanoparticles (NPs) (CRM197/PBCA NPs) to carry zidovudine (AZT) across the blood-brain barrier (BBB). AZT was loaded on CRM197/PBCA NPs to traverse the monolayer of human brain-microvascular endothelial cells (HBMECs) regulated by human astrocytes. The particle size distribution of AZT-loaded CRM197/PBCA NPs was quite uniform. In addition, AZT-loaded CRM197/PBCA NPs displayed a spherical shape with slightly fluffy exterior. The deposited thin film of AZT-loaded CRM197/PBCA NPs exhibited a hexagonal lattice-like geometry. When the diameter of AZT-loaded CRM197/PBCA NPs decreased, the loading efficiency of AZT on the drug carriers and the permeability coefficient of AZT across the BBB enhanced. An increase in the grafting quantity of CRM197 enhanced the permeability coefficient of AZT across the BBB and the uptake quantity of AZT-loaded CRM197/PBCA NPs by HBMECs. CRM197/PBCA NPs can be promising brain-targeting carriers for delivering AZT across the BBB.
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| http://dx.doi.org/10.1016/j.colsurfb.2011.11.007 | DOI Listing |
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