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Background: Ceftolozane-tazobactam and ceftazidime-avibactam are preferred treatment options for multidrug-resistant Pseudomonas aeruginosa infections; however, real-world comparative effectiveness studies are scarce. Pharmacokinetic and pharmacodynamic differences between the agents might affect clinical response rates. We aimed to compare the effectiveness of ceftolozane-tazobactam and ceftazidime-avibactam for treatment of invasive multidrug-resistant P aeruginosa infections.
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- Translation initiation significantly influences gene expression in eukaryotes, with eukaryotic initiation factor 3 (eIF3) playing a key role in recruiting ribosomes.
- This study examined how eIF3's binding to specific 5'-untranslated regions (5'-UTRs) of mRNAs leads to varying protein outputs, finding that it binds to a specific motif, AMAYAA, in some 5'-UTRs.
- The study demonstrates that mRNAs bound by eIF3 have higher ribosome density and are preferentially translated during stress, highlighting eIF3's role as a novel translational enhancer.
Culturally responsive strategies and practical considerations for live tissue studies in Māori participant cohorts.
Front Res Metr Anal
November 2024
Department of Physiology, University of Otago, Dunedin, New Zealand.
Introduction: Indigenous communities globally are inequitably affected by non-communicable diseases such as cancer and coronary artery disease. Increased focus on personalized medicine approaches for the treatment of these diseases offers opportunities to improve the health of Indigenous people. Conversely, poorly implemented approaches pose increased risk of further exacerbating current inequities in health outcomes for Indigenous peoples.
View Article and Find Full Text PDFLatent class analysis of actigraphy within the depression early warning (DEW) longitudinal clinical youth cohort.
Child Adolesc Psychiatry Ment Health
November 2024
Centre for Child and Youth Depression Centre for Addiction & Mental Health, Toronto, ON, Canada.
Background: Wearable-generated data yield objective information on physical activity and sleep variables, which, are in turn, related to the phenomenology of depression. There is a dearth of wearable-generated data regarding physical activity and sleep variables among youth with clinical depression.
Methods: Longitudinal (up to 24 months) quarterly collections of wearable-generated variables among adolescents diagnosed with current/past major depression.
Cancer cachexia, and the related loss of muscle and strength, worsens quality of life and lowers overall survival. Recently, a novel 'pre-atrophy' muscle weakness was identified during early-stage cancer. While mitochondrial stress responses are associated with early-stage pre-atrophy weakness, a causal relationship has not been established.
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