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| http://dx.doi.org/10.1289/ehp.119-a510 | DOI Listing |
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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
McGill University, Montreal, QC, Canada.
Background: Intracellular accumulation of tau tangles in the brain is one of the most prominent manifestations of Alzheimer's disease (AD). Progression thereof across the AD stages has specific temporal and spatial patterns, wherein time is informative of space and vice versa. Here we introduce a novel method, Manifold Component Analysis (MCA), to represent tangle accumulation in 2D, reflecting the spatial aspect of tau propagation stages to further relate it to the temporal aspect thereof.
View Article and Find Full Text PDFProteogenomic approaches for snake venom protein-based drug development: current trends and challenges.
Trans R Soc Trop Med Hyg
January 2025
Metabolomics and Proteomics Laboratory, Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal 462003, India.
Snake venom proteins have long been recognized for their therapeutic potential. Proteogenomic strategies, integrating transcriptomics and proteomics, have emerged as powerful tools for identifying and characterizing venom proteins for the development of novel therapeutic agents. Analytical techniques like mass spectrometry and next-generation sequencing enable comprehensive analysis, identifying key venom components and their variants.
View Article and Find Full Text PDFSpanning three decades: global research wave and future prospects of broader autism phenotype-a visual researches by CiteSpace and VOS viewer.
Front Psychol
December 2024
Department of Rehabilitation Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Objectives: To conduct a comprehensive review of the literature pertaining to the broader autism phenotype, the paper endeavors to delineate the key research directions and topics, document the current research trends, and furnish insightful analyses and novel perspectives to foster future advancements in the field, with the aid of CiteSpace and VOS viewer.
Methods: CiteSpace and VOS viewer are two kinds of software for visualizing citations that is intended to examine academic literature and identify possible sources of knowledge. The Web of Science Core Collection database was used to retrieve articles from 1994 to 2024 that discussed the autism phenotype in general.
A comprehensive analysis of advanced solar panel productivity and efficiency through numerical models and emotional neural networks.
Sci Rep
January 2025
Computational Data Science Program, College of Computational and Natural Science, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
This study presents an in-depth analysis and evaluation of the performance of a standard 200 W solar cell, focusing on the energy and exergy aspects. A significant research gap exists in the comprehensive integration of numerical models with advanced machine-learning approaches, specifically emotional artificial neural networks (EANN), to simulate and optimize the electrical characteristics and efficiency of solar panels. To address this gap, a numerical model alongside a novel EANN was employed to simulate the system's electrical characteristics, including open-circuit voltage, short-circuit current, system resistances, maximum power point characteristics, and characteristic curves.
View Article and Find Full Text PDFHypoalbuminemia as a predictor of severe dengue: a systematic review and meta-analysis.
Expert Rev Anti Infect Ther
January 2025
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Article Synopsis
- Dengue fever is a major health issue globally, particularly in tropical regions, where identifying hypoalbuminemia helps in diagnosing severe cases early.
- A systematic review of 17 studies found a significant difference in albumin levels between severe and non-severe dengue patients, with higher hypoalbuminemia noted in children.
- The research confirms that low albumin levels are a key predictor of severe dengue, which can help healthcare providers improve patient care through tailored treatment plans.
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