This study was designed to investigate the protective effects of the combination of guanosine and 2 organoselenium compounds (ebselen and diphenyl diselenide) against glutamate-induced oxidative stress in different regions of rat brains. Glutamate caused an increase in reactive oxygen species (ROS) generation and a decrease in [(3)H]-glutamate uptake in striatal, cortical, and hippocampal slices. Guanosine, ebselen, and diphenyl diselenide prevented glutamate-induced ROS production in striatal, cortical and hippocampal slices. The combination of guanosine with organoselenium compounds was more effective against glutamate-induced ROS production than the individual compounds alone. Guanosine prevented [(3)H]-glutamate uptake inhibition in striatal, cortical, and hippocampal slices. Thus, protection against the harmful effects of glutamate is possibly due to the combination of the antioxidant properties of organoselenium compounds and the stimulatory effect of guanosine on glutamate uptake. In conclusion, the combination of antioxidants and glutamatergic system modulators could be considered a potential therapy against the prooxidant effects of glutamate.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.brainres.2011.10.049 | DOI Listing |
Future Med Chem
December 2024
Chemistry Division, School of Advanced Sciences (SAS), Vellore Institute of Technology - Chennai, Chennai, India.
Organoselenium chemistry has become a significant field due to its role in synthesizing numerous biologically active and therapeutic compounds. In early phase, researchers focused on designing organoselenium compounds with antioxidant properties and were quite successful. In last two decades, synthetic chemists shifted their focus toward synthesis of organoselenium compounds with biological properties, moving beyond their traditional antioxidant properties.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Research Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Herein, we describe a novel coupling between ambiphilic 2-pyridylselenyl reagents and nitriles featuring an active α-methylene group. Depending on the solvent employed, this reaction can yield two distinct types of cationic pyridinium-fused selenium-containing heterocycles, 1,3-selenazolium or 1,2,4-selenadiazolium salts, in high yields. This is in contrast to what we observed before for other nitriles.
View Article and Find Full Text PDFMolecules
November 2024
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Organosulfur- and organoselenium-containing compounds play a crucial role in organic synthesis [...
View Article and Find Full Text PDFJ Int Adv Otol
November 2024
Department of Pathology, Haydarpaşa Training and Research Hospital, İstanbul, Türkiye.
Background: Ebselen is a neuroprotective drug that protects cellular components from oxidative damage by modulating enzymatic cofactors, metalloproteins, gene expression, antioxidant-anti-inflammatory effects, and immunological systems. Our goal was to compare the efficacy of Ebselen and methylprednisolone on rat facial nerve crush injury.
Methods: Thirty healthy male Wistar rats (mean weight of 245 g) were used in this study.
Chemistry
December 2024
Department of Chemistry, Indian Institute of Technology Guwahati, 781039, Guwahati, Assam, India.
Organoselenocyanates are important classes of organoselenium compounds having potential pharmaceutical applications in cancer biology. In the present study, two different series of organoselenocyanates (15 a-15 c and 16 a-16 c) incorporating crucial heterocyclic pharmacophores such as 2,4-thiazolidine-1,3-dione and 1,2,3-triazole were rationally designed. The organoselenocyanates were synthesized using multi-step organic synthesis and investigated for their anticancer activities against triple-negative breast cancer cells.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!