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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission.
Sci Rep
January 2025
Translational and Clinical Research Institute, Newcastle University Medical School, Newcastle upon Tyne, NE2 4HH, GB, United Kingdom.
SARS-CoV-2 is the viral pathogen responsible for COVID-19. Although morbidity and mortality frequently occur as a result of lung disease, the gastrointestinal (GI) tract is recognized as a primary location for SARS-CoV-2. Connections and interactions between the microbiome of the gut and respiratory system have been linked with viral infections via what has been referred to as the 'gut-lung axis' with potential aerodigestive communication in health and disease.
View Article and Find Full Text PDFEfficacy of endoscopic radiofrequency ablation for proton pump inhibitor-dependent gastroesophageal reflux disease: Multicenter prospective cohort study.
Dig Endosc
December 2024
Department of Gastroenterology, Tongji Hospital，School of Medicine, Tongji University, Shanghai, China.
Article Synopsis
- The study assessed the impact of endoscopic radiofrequency ablation (RFA) on patients in China with gastroesophageal reflux disease (GERD) who depend on proton pump inhibitors (PPIs).
- Results showed significant improvements in GERD-related quality of life and symptom relief over a period of up to four years post-treatment.
- Factors like younger age, higher body mass index, lower acid exposure time, and higher lower esophageal sphincter pressure were associated with better outcomes from the RFA procedure.
Overall satisfaction following laparoscopic fundoplication for patients with atypical extraesophageal symptoms: A comparative cohort study.
World J Surg
January 2025
Discipline of Surgery, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Background: Some patients with gastroesophageal reflux (GERD) experience extraesophageal symptoms, which are considered due to laryngopharyngeal reflux (LPR). Most studies evaluating fundoplication for LPR report outcomes from individuals who also have typical esophageal GERD symptoms. Information is limited for patients with LPR but no GERD symptoms.
View Article and Find Full Text PDF[Features of gastroesophageal reflux disease in elderly patients (literature review).].
Adv Gerontol
November 2024
S.M.Kirov Military Medical Academy, 6 Academician Lebedev str., St. Petersburg 194044, Russian Federation, e-mail:
In recent years, there has been an increase in the incidence of gastroesophageal reflux disease (GERD) in the elderly not only in our country, but also worldwide. In this regard, the issues of early diagnosis and development of an individualized approach to the treatment of this disease are of particular relevance. When addressing these issues, it is necessary to take into account a number of features in patients of older age groups, which include polymorbidity and polypharmacotherapy in combination with anatomical, physiological and functional age-related changes.
View Article and Find Full Text PDFA systematic review and meta-analysis exploring the bidirectional association between asthma and gastroesophageal reflux disease in children.
Allergy Asthma Proc
November 2024
Department of Pediatrics Respiratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Clinical Research Center for Children's Health and Disease Office, Ji'nan, China.
Asthma is the most prevalent chronic respiratory disease in children, and gastroesophageal reflux disease (GERD) is one of its extraesophageal complications of asthma. Both conditions are commonly observed in pediatric outpatient clinics, but the causality between them in children is still debated. Therefore, we conducted a systematic review and meta-analysis to evaluate the bidirectional association between asthma and GERD in children.
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