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Lipid organization by the Caveolin-1 complex.
Biophys J
November 2024
Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, Illinois. Electronic address:
Caveolins are lipid-binding proteins that can organize membrane remodeling and oligomerize into the 8S complex. The CAV1-8S complex comprises a disk-like structure, about 15 nm in diameter, with a central beta barrel. Further oligomerization of 8S complexes remodels the membrane into caveolae vessels, with a dependence on cholesterol concentration.
View Article and Find Full Text PDFRole of STIM1 in stretch-induced signaling in human airway smooth muscle.
Am J Physiol Lung Cell Mol Physiol
August 2024
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.
Alteration in the normal mechanical forces of breathing can contribute to changes in contractility and remodeling characteristic of airway diseases, but the mechanisms that mediate these effects in airway cells are still under investigation. Airway smooth muscle (ASM) cells contribute to both contractility and extracellular matrix (ECM) remodeling. In this study, we explored ASM mechanisms activated by mechanical stretch, focusing on mechanosensitive piezo channels and the key Ca regulatory protein stromal interaction molecule 1 (STIM1).
View Article and Find Full Text PDFROCK1 deficiency preserves caveolar compartmentalization of signaling molecules and cell membrane integrity.
FASEB Bioadv
March 2024
Herman B Wells Center for Pediatric Research, Department of Pediatrics, School of Medicine Indiana University Indianapolis Indiana USA.
In this study, we investigated the roles of ROCK1 in regulating structural and functional features of caveolae located at the cell membrane of cardiomyocytes, adipocytes, and mouse embryonic fibroblasts (MEFs) as well as related physiopathological effects. Caveolae are small bulb-shaped cell membrane invaginations, and their roles have been associated with disease conditions. One of the unique features of caveolae is that they are physically linked to the actin cytoskeleton that is well known to be regulated by RhoA/ROCKs pathway.
View Article and Find Full Text PDFCav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation.
J Cell Mol Med
February 2024
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Background And Aims: The secretion of bile salts transported by the bile salt export pump (BSEP) is the primary driving force for the generation of bile flow; thus, it is closely related to the formation of cholesterol stones. Caveolin-1 (Cav-1), an essential player in cell signalling and endocytosis, is known to co-localize with cholesterol-rich membrane domains. This study illustrates the role of Cav-1 and BSEP in cholesterol stone formation.
View Article and Find Full Text PDFAcute, pro-contractile effects of prorenin on rat mesenteric arteries.
FASEB J
December 2023
Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark.
Article Synopsis
- Prorenin and its receptor ((P)RR) play significant roles in the renin-angiotensin-aldosterone system, with (P)RR found in various body tissues, including blood vessels, but its impact on arterial contractility remains unclear.
- Research using rat mesenteric arteries identified key interactions of (P)RR with important proteins in vascular smooth muscle cells (VSMCs) and revealed that prorenin increases arterial contraction through the α1-adrenoreceptor, enhancing calcium release without engaging voltage-gated calcium channels.
- The study concluded that prorenin boosts arterial contractility by inhibiting BK channels and promoting intracellular calcium release, likely via a localized pH shift facilitated by (P)RR
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